Nalfurafine, a G-Protein-Biased KOR (Kappa Opioid Receptor) Agonist, Enhances the Diuretic Response and Limits Electrolyte Losses to Standard-of-Care Diuretics.

Meariman, Jacob K; Sutphen, Jane C; Gao, Juan; Kapusta, Daniel R

Meariman, Jacob K; Sutphen, Jane C; Gao, Juan; Kapusta, Daniel R.

Afiliação

Meariman JK; Department of Pharmacology and Experimental Therapeutics (J.K.M., J.C.S., J.G., D.R.K.), Louisiana State University Health Sciences Center, 1901 Perdido St, New Orleans, LA.
Sutphen JC; Department of Pharmacology and Experimental Therapeutics (J.K.M., J.C.S., J.G., D.R.K.), Louisiana State University Health Sciences Center, 1901 Perdido St, New Orleans, LA.
Gao J; Department of Pharmacology and Experimental Therapeutics (J.K.M., J.C.S., J.G., D.R.K.), Louisiana State University Health Sciences Center, 1901 Perdido St, New Orleans, LA.
Kapusta DR; Department of Pharmacology and Experimental Therapeutics (J.K.M., J.C.S., J.G., D.R.K.), Louisiana State University Health Sciences Center, 1901 Perdido St, New Orleans, LA.

Hypertension ; 79(2): 379-390, 2022 02.

Article em En | MEDLINE | ID: mdl-34852633

Assuntos

Analgésicos Opioides/farmacologia; Diurese/efeitos dos fármacos; Diuréticos/farmacologia; Morfinanos/farmacologia; Receptores Opioides kappa/agonistas; Compostos de Espiro/farmacologia; Animais; Furosemida/farmacologia; Hidroclorotiazida/farmacologia; Rim/efeitos dos fármacos; Masculino; Ratos; Ratos Sprague-Dawley

Palavras-chave

diuresis; furosemide; hydrochlorothiazide; rats; receptor, opioid, kappa

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Compostos de Espiro / Receptores Opioides kappa / Diurese / Diuréticos / Analgésicos Opioides / Morfinanos Idioma: En Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Laos

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