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The contribution of behavioral features to caregiver burden in FTLD spectrum disorders.
Silverman, Hannah E; Ake, Jeannie M; Manoochehri, Masood; Appleby, Brian S; Brushaber, Danielle; Devick, Katrina L; Dickerson, Bradford C; Fields, Julie A; Forsberg, Leah K; Ghoshal, Nupur; Graff-Radford, Neill R; Grossman, Murray; Heuer, Hilary W; Kornak, John; Lapid, Maria I; Litvan, Irene; Mackenzie, Ian R; Mendez, Mario F; Onyike, Chiadi U; Pascual, Belen; Tartaglia, Maria Carmela; Boeve, Bradley F; Boxer, Adam L; Rosen, Howard J; Cosentino, Stephanie; Huey, Edward D; Barker, Megan S; Goldman, Jill S.
Afiliação
  • Silverman HE; Taub Institute for Research on Alzheimer's Disease and the Aging Brain and Gertrude H. Sergievsky Center, Department of Neurology, Columbia University Irving Medical Center, New York, New York, USA.
  • Ake JM; Taub Institute for Research on Alzheimer's Disease and the Aging Brain and Gertrude H. Sergievsky Center, Department of Neurology, Columbia University Irving Medical Center, New York, New York, USA.
  • Manoochehri M; Taub Institute for Research on Alzheimer's Disease and the Aging Brain and Gertrude H. Sergievsky Center, Department of Neurology, Columbia University Irving Medical Center, New York, New York, USA.
  • Appleby BS; Department of Neurology, Case Western Reserve University, Cleveland, Ohio, USA.
  • Brushaber D; Division of Clinical Trials and Biostatistics, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota, USA.
  • Devick KL; Division of Clinical Trials and Biostatistics, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota, USA.
  • Dickerson BC; Department of Neurology, Frontotemporal Disorders Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
  • Fields JA; Division of Neurocognitive Disorders, Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota, USA.
  • Forsberg LK; Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
  • Ghoshal N; Department of Neurology, Washington University, St. Louis, Missouri, USA.
  • Graff-Radford NR; Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA.
  • Grossman M; Penn Frontotemporal Degeneration Center, Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Heuer HW; Department of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco, California, USA.
  • Kornak J; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA.
  • Lapid MI; Division of Neurocognitive Disorders, Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota, USA.
  • Litvan I; Department of Neuroscience, University of California, San Diego, San Diego, California, USA.
  • Mackenzie IR; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
  • Mendez MF; Department of Neurology, University of California, Los Angeles, California, USA.
  • Onyike CU; Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, California, USA.
  • Pascual B; Division of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, Maryland, USA.
  • Tartaglia MC; Stanley H. Appel Department of Neurology, Houston Methodist Hospital, Weill Cornell Medicine, Houston Methodist Neurological and Research Institute, Houston, Texas, USA.
  • Boeve BF; Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
  • Boxer AL; Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
  • Rosen HJ; Department of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco, California, USA.
  • Cosentino S; Department of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco, California, USA.
  • Huey ED; Taub Institute for Research on Alzheimer's Disease and the Aging Brain and Gertrude H. Sergievsky Center, Department of Neurology, Columbia University Irving Medical Center, New York, New York, USA.
  • Barker MS; Taub Institute for Research on Alzheimer's Disease and the Aging Brain and Gertrude H. Sergievsky Center, Department of Neurology, Columbia University Irving Medical Center, New York, New York, USA.
  • Goldman JS; Department of Psychiatry and New York Psychiatric Institute, Columbia University Medical Center, New York, USA.
Alzheimers Dement ; 18(9): 1635-1649, 2022 09.
Article em En | MEDLINE | ID: mdl-34854532
ABSTRACT

INTRODUCTION:

Caregivers of patients with frontotemporal lobar degeneration (FTLD) spectrum disorders experience tremendous burden, which has been associated with the neuropsychiatric and behavioral features of the disorders.

METHODS:

In a sample of 558 participants with FTLD spectrum disorders, we performed multiple-variable regressions to identify the behavioral features that were most strongly associated with caregiver burden, as measured by the Zarit Burden Interview, at each stage of disease.

RESULTS:

Apathy and disinhibition, as rated by both clinicians and caregivers, as well as clinician-rated psychosis, showed the strongest associations with caregiver burden, a pattern that was consistent when participants were separated cross-sectionally by disease stage. In addition, behavioral features appeared to contribute most to caregiver burden in patients with early dementia.

DISCUSSION:

Caregivers should be provided with early education on the management of the behavioral features of FTLD spectrum disorders. Interventions targeting apathy, disinhibition, and psychosis may be most useful to reduce caregiver burden.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Degeneração Lobar Frontotemporal / Demência Frontotemporal / Apatia Idioma: En Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Degeneração Lobar Frontotemporal / Demência Frontotemporal / Apatia Idioma: En Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos