Low Serum Calcitonin Gene-Related Peptide Level is Associated with Severity of Coronary Stenosis.
Clin Invest Med
; 44(4): E23-30, 2021 12 31.
Article
em En
| MEDLINE
| ID: mdl-34978769
ABSTRACT
PURPOSE:
To evaluate the relationship between the serum calcitonin gene-related peptide (CGRP) level and severity of coronary stenosis.METHODS:
A total of 233 eligible patients who underwent coronary angiography were divided into two groups a control and a coronary heart disease (CHD) group. The angiographic severity of coronary stenosis was evaluated by SYNTAX and Gensini scores. The incidence of major adverse cardiovascular events within two years was collected.RESULTS:
A negative correlation between serum CGRP levels and Gensini scores was observed in all patients (r=-0.352, p<0.001), the control group (r=-0.422, p<0.001) and the CHD group (r=-0.393, p<0.001). Serum CGRP levels were negatively associated with SYNTAX scores in the CHD group (r=-0.522, p<0.001). The area under the curve of CGRP for identifying high SYNTAX scores (>22) was 0.772 [95% confidence interval (CI) 0.673-0.870, p<0.001], and for identifying high Gensini scores was 0.744 (95% CI 0.646-0.842, p<0.001). A CGRP concentration of 25.05 pg/ml was selected as the cutoff point. A low CGRP level (<25.05 pg/ml) was an independent predictor of severe coronary stenosis, a SYNTAX score >22 [odds ratio (OR) =5.819, 95% CI 2.240-15.116; p<0.001] and a high Gensini score (>64) (OR=4.943, 95% CI 2.020-12.095; p<0.001). The low CGRP group had a higher incidence of major adverse cardiovascular events within two years (11.1 vs. 3.1%, p=0.031).CONCLUSION:
In coronary atherosclerosis patients without acute myocardial injury, serum CGRP levels were negatively associated with the severity of coronary stenosis.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Doença da Artéria Coronariana
/
Estenose Coronária
/
Aterosclerose
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article