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Microbowls with Controlled Concavity for Accurate Microscale Mass Spectrometry.
Xu, Linfeng; Li, Xiangpeng; Li, Wenzong; Chang, Kai-Chun; Yang, Hyunjun; Tao, Nannan; Zhang, Pengfei; Payne, Emory M; Modavi, Cyrus; Humphries, Jacqueline; Lu, Chia-Wei; Abate, Adam R.
Afiliação
  • Xu L; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, 94158, USA.
  • Li X; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, 94158, USA.
  • Li W; Amyris Inc., 5885 Hollis St #100, Emeryville, CA, 94608, USA.
  • Chang KC; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, 94158, USA.
  • Yang H; Institute for Neurodegenerative Diseases, Weill Institute for Neurosciences, University of California, San Francisco, CA, 94158, USA.
  • Tao N; Bruker Nano Surfaces, San Jose, CA, 95134, USA.
  • Zhang P; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, 94158, USA.
  • Payne EM; Department of Chemistry, University of Michigan, Ann Arbor, MI, 48104, USA.
  • Modavi C; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, 94158, USA.
  • Humphries J; Amyris Inc., 5885 Hollis St #100, Emeryville, CA, 94608, USA.
  • Lu CW; Amyris Inc., 5885 Hollis St #100, Emeryville, CA, 94608, USA.
  • Abate AR; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, 94158, USA.
Adv Mater ; 34(12): e2108194, 2022 Mar.
Article em En | MEDLINE | ID: mdl-35045587
ABSTRACT
Patterned surfaces can enhance the sensitivity of laser desorption ionization mass spectrometry by segregating and concentrating analytes, but their fabrication can be challenging. Here, a simple method to fabricate substrates patterned with micrometer-scale wells that yield more accurate and sensitive mass spectrometry measurements compared to flat surfaces is described. The wells can also concentrate and localize cells and beads for cell-based assays.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Lasers / Luz Idioma: En Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Lasers / Luz Idioma: En Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos