Your browser doesn't support javascript.
loading
Efficacy of an inactivated Zika vaccine against virus infection during pregnancy in mice and marmosets.
Kim, In-Jeong; Lanthier, Paula A; Clark, Madeline J; De La Barrera, Rafael A; Tighe, Michael P; Szaba, Frank M; Travis, Kelsey L; Low-Beer, Timothy C; Cookenham, Tres S; Lanzer, Kathleen G; Bernacki, Derek T; Johnson, Lawrence L; Schneck, Amanda A; Ross, Corinna N; Tardif, Suzette D; Layne-Colon, Donna; Mdaki, Stephanie D; Dick, Edward J; Chuba, Colin; Gonzalez, Olga; Brasky, Kathleen M; Dutton, John; Rutherford, Julienne N; Coffey, Lark L; Singapuri, Anil; Martin, Claudia Sanchez San; Chiu, Charles Y; Thomas, Stephen J; Modjarrad, Kayvon; Patterson, Jean L; Blackman, Marcia A.
Afiliação
  • Kim IJ; Trudeau Institute, Inc., Saranac Lake, NY, 12983, USA. ijkim@trudeauinstitute.org.
  • Lanthier PA; Trudeau Institute, Inc., Saranac Lake, NY, 12983, USA.
  • Clark MJ; Trudeau Institute, Inc., Saranac Lake, NY, 12983, USA.
  • De La Barrera RA; Pilot Bioproduction Facility, Center for Enabling Capabilities, Walter Reed Army Institute of Research, Silver Spring, MD, 20910, USA.
  • Tighe MP; Trudeau Institute, Inc., Saranac Lake, NY, 12983, USA.
  • Szaba FM; Trudeau Institute, Inc., Saranac Lake, NY, 12983, USA.
  • Travis KL; Trudeau Institute, Inc., Saranac Lake, NY, 12983, USA.
  • Low-Beer TC; Trudeau Institute, Inc., Saranac Lake, NY, 12983, USA.
  • Cookenham TS; Trudeau Institute, Inc., Saranac Lake, NY, 12983, USA.
  • Lanzer KG; Trudeau Institute, Inc., Saranac Lake, NY, 12983, USA.
  • Bernacki DT; Trudeau Institute, Inc., Saranac Lake, NY, 12983, USA.
  • Johnson LL; Trudeau Institute, Inc., Saranac Lake, NY, 12983, USA.
  • Schneck AA; Trudeau Institute, Inc., Saranac Lake, NY, 12983, USA.
  • Ross CN; Southwest National Primate Center, Texas Biomedical Research Institute, San Antonio, TX, 78227, USA.
  • Tardif SD; Southwest National Primate Center, Texas Biomedical Research Institute, San Antonio, TX, 78227, USA.
  • Layne-Colon D; Southwest National Primate Center, Texas Biomedical Research Institute, San Antonio, TX, 78227, USA.
  • Mdaki SD; Southwest National Primate Center, Texas Biomedical Research Institute, San Antonio, TX, 78227, USA.
  • Dick EJ; Southwest National Primate Center, Texas Biomedical Research Institute, San Antonio, TX, 78227, USA.
  • Chuba C; Southwest National Primate Center, Texas Biomedical Research Institute, San Antonio, TX, 78227, USA.
  • Gonzalez O; Southwest National Primate Center, Texas Biomedical Research Institute, San Antonio, TX, 78227, USA.
  • Brasky KM; Southwest National Primate Center, Texas Biomedical Research Institute, San Antonio, TX, 78227, USA.
  • Dutton J; Southwest National Primate Center, Texas Biomedical Research Institute, San Antonio, TX, 78227, USA.
  • Rutherford JN; Department of Human Development Nursing Science, College of Nursing, University of Illinois Chicago, Chicago, IL, 60612, USA.
  • Coffey LL; Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, CA, 95616, USA.
  • Singapuri A; Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis, CA, 95616, USA.
  • Martin CSS; Department of Laboratory Medicine, School of Medicine, University of California at San Francisco, San Francisco, CA, 94158, USA.
  • Chiu CY; Division of Infectious Diseases and Vaccinology, School of Public Health, University of California at Berkeley, Berkeley, CA, 94720, USA.
  • Thomas SJ; Department of Laboratory Medicine, School of Medicine, University of California at San Francisco, San Francisco, CA, 94158, USA.
  • Modjarrad K; Division of Infectious Diseases, Institute for Global Health and Translational Sciences, State University of New York, Upstate Medical University, Syracuse, NY, 13210, USA.
  • Patterson JL; Emerging Infectious Diseases Branch, Walter Reed Army Institute of Research, Silver Spring, MD, 20910, USA.
  • Blackman MA; Southwest National Primate Center, Texas Biomedical Research Institute, San Antonio, TX, 78227, USA. jpatters@txbiomed.org.
NPJ Vaccines ; 7(1): 9, 2022 Jan 27.
Article em En | MEDLINE | ID: mdl-35087081
ABSTRACT
Zika virus (ZIKV) is a mosquito-borne arbovirus that can cause severe congenital birth defects. The utmost goal of ZIKV vaccines is to prevent both maternal-fetal infection and congenital Zika syndrome. A Zika purified inactivated virus (ZPIV) was previously shown to be protective in non-pregnant mice and rhesus macaques. In this study, we further examined the efficacy of ZPIV against ZIKV infection during pregnancy in immunocompetent C57BL6 mice and common marmoset monkeys (Callithrix jacchus). We showed that, in C57BL/6 mice, ZPIV significantly reduced ZIKV-induced fetal malformations. Protection of fetuses was positively correlated with virus-neutralizing antibody levels. In marmosets, the vaccine prevented vertical transmission of ZIKV and elicited neutralizing antibodies that remained above a previously determined threshold of protection for up to 18 months. These proof-of-concept studies demonstrate ZPIV's protective efficacy is both potent and durable and has the potential to prevent the harmful consequence of ZIKV infection during pregnancy.
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos