Identification through action potential clamp of proarrhythmic consequences of the short QT syndrome T618I hERG 'hotspot' mutation.

Du, Chunyun; Zhang, Henggui; Harmer, Stephen C; Hancox, Jules C

Du, Chunyun; Zhang, Henggui; Harmer, Stephen C; Hancox, Jules C.

Afiliação

Du C; School of Physiology, Pharmacology and Neuroscience, Biomedical Sciences Building, University Walk, Bristol, BS8 1TD, UK.
Zhang H; Biological Physics Group, Department of Physics and Astronomy, The University of Manchester, Manchester, M13 9PL, UK.
Harmer SC; School of Physiology, Pharmacology and Neuroscience, Biomedical Sciences Building, University Walk, Bristol, BS8 1TD, UK.
Hancox JC; School of Physiology, Pharmacology and Neuroscience, Biomedical Sciences Building, University Walk, Bristol, BS8 1TD, UK; Biological Physics Group, Department of Physics and Astronomy, The University of Manchester, Manchester, M13 9PL, UK. Electronic address: jules.hancox@bristol.ac.uk.

Biochem Biophys Res Commun ; 596: 49-55, 2022 03 12.

Article em En | MEDLINE | ID: mdl-35114584

Assuntos

Potenciais de Ação/genética; Arritmias Cardíacas/genética; Canal de Potássio ERG1/genética; Mutação; Técnicas de Patch-Clamp/métodos; Eletrocardiografia/métodos; Células HEK293; Átrios do Coração/metabolismo; Ventrículos do Coração/metabolismo; Humanos; Ramos Subendocárdicos/metabolismo

Palavras-chave

Arrhythmia; I(Kr); Rapid delayed rectifier; SQTS; Short QT syndrome; hERG

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Arritmias Cardíacas / Potenciais de Ação / Técnicas de Patch-Clamp / Canal de Potássio ERG1 / Mutação Idioma: En Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Reino Unido

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