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Investigating the phenotypic and genetic associations between personality traits and suicidal behavior across major mental health diagnoses.
Kalman, Janos L; Yoshida, Tomoya; Andlauer, Till F M; Schulte, Eva C; Adorjan, Kristina; Alda, Martin; Ardau, Raffaela; Aubry, Jean-Michel; Brosch, Katharina; Budde, Monika; Chillotti, Caterina; Czerski, Piotr M; DePaulo, Raymond J; Forstner, Andreas; Goes, Fernando S; Grigoroiu-Serbanescu, Maria; Grof, Paul; Grotegerd, Dominik; Hahn, Tim; Heilbronner, Maria; Hasler, Roland; Heilbronner, Urs; Heilmann-Heimbach, Stefanie; Kapelski, Pawel; Kato, Tadafumi; Kohshour, Mojtaba Oraki; Meinert, Susanne; Meller, Tina; Nenadic, Igor; Nöthen, Markus M; Novak, Tomas; Opel, Nils; Pawlak, Joanna; Pfarr, Julia-Katharina; Potash, James B; Reich-Erkelenz, Daniela; Repple, Jonathan; Richard-Lepouriel, Hélène; Rietschel, Marcella; Ringwald, Kai G; Rouleau, Guy; Schaupp, Sabrina; Senner, Fanny; Severino, Giovanni; Squassina, Alessio; Stein, Frederike; Stopkova, Pavla; Streit, Fabian; Thiel, Katharina; Thomas-Odenthal, Florian.
Afiliação
  • Kalman JL; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Nussbaumstr. 7, 80336, Munich, Germany. janos.kalman@med.uni-muenchen.de.
  • Yoshida T; Department of Psychiatry and Psychotherapy, University Hospital Munich, Munich, Germany. janos.kalman@med.uni-muenchen.de.
  • Andlauer TFM; International Max Planck Research School for Translational Psychiatry, Munich, Germany. janos.kalman@med.uni-muenchen.de.
  • Schulte EC; National Center for Global Health and Medicine, Tokyo, Japan.
  • Adorjan K; Department of Neurology, Klinikum Rechts Der Isar, School of Medicine, Technical University of Munich, Munich, Germany.
  • Alda M; Global Computational Biology and Data Sciences, Boehringer Ingelheim Pharma GmbH & Co. KG, 88397, Biberach an der Riß, Germany.
  • Ardau R; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Nussbaumstr. 7, 80336, Munich, Germany.
  • Aubry JM; Department of Psychiatry and Psychotherapy, University Hospital Munich, Munich, Germany.
  • Brosch K; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Nussbaumstr. 7, 80336, Munich, Germany.
  • Budde M; Department of Psychiatry and Psychotherapy, University Hospital Munich, Munich, Germany.
  • Chillotti C; Department of Psychiatry, Dalhousie University, Halifax, Canada.
  • Czerski PM; Unit of Clinical Pharmacology, University Hospital Agency of Cagliari, Cagliari, Italy.
  • DePaulo RJ; Department of Psychiatry, Geneva University Hospitals, Geneva, Switzerland.
  • Forstner A; Faculty of Medicine, University of Geneva, Geneva, Switzerland.
  • Goes FS; Department of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.
  • Grigoroiu-Serbanescu M; Center for Mind, Brain and Behavior, University of Marburg, Marburg, Germany.
  • Grof P; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Nussbaumstr. 7, 80336, Munich, Germany.
  • Grotegerd D; Unit of Clinical Pharmacology, University Hospital Agency of Cagliari, Cagliari, Italy.
  • Hahn T; Department of Psychiatric Genetics, Poznan University of Medical Sciences, Poznan, Poland.
  • Heilbronner M; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Hasler R; Centre for Human Genetics, University of Marburg, Marburg, Germany.
  • Heilbronner U; Institute of Human Genetics, School of Medicine &, University of Bonn, University Hospital Bonn, Bonn, Germany.
  • Heilmann-Heimbach S; Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, Jülich, Germany.
  • Kapelski P; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
  • Kato T; Psychiatric Genetics Research Unit, Alexandru Obregia Clinical Psychiatric Hospital, Bucharest, Romania.
  • Kohshour MO; Mood Disorders Clinic of Ottawa, Ottawa, ON, Canada.
  • Meinert S; Department of Psychiatry, University of Toronto, Toronto, ON, Canada.
  • Meller T; Institute for Translational Psychiatry, University of Munster, Munster, Germany.
  • Nenadic I; Institute for Translational Psychiatry, University of Munster, Munster, Germany.
  • Nöthen MM; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Nussbaumstr. 7, 80336, Munich, Germany.
  • Novak T; Department of Psychiatry, Geneva University Hospitals, Geneva, Switzerland.
  • Opel N; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Nussbaumstr. 7, 80336, Munich, Germany.
  • Pawlak J; Institute of Human Genetics, School of Medicine &, University of Bonn, University Hospital Bonn, Bonn, Germany.
  • Pfarr JK; Department of Psychiatric Genetics, Poznan University of Medical Sciences, Poznan, Poland.
  • Potash JB; Department of Psychiatry and Behavioral Science, Juntendo University Graduate School of Medicine, Tokyo, Japan.
  • Reich-Erkelenz D; Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Nussbaumstr. 7, 80336, Munich, Germany.
  • Repple J; Department of Immunology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
  • Richard-Lepouriel H; Institute for Translational Psychiatry, University of Munster, Munster, Germany.
  • Rietschel M; Institute for Translational Neuroscience, University of Münster, Munster, Germany.
  • Ringwald KG; Department of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.
  • Rouleau G; Center for Mind, Brain and Behavior, University of Marburg, Marburg, Germany.
  • Schaupp S; Department of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.
  • Senner F; Center for Mind, Brain and Behavior, University of Marburg, Marburg, Germany.
  • Severino G; Institute of Human Genetics, School of Medicine &, University of Bonn, University Hospital Bonn, Bonn, Germany.
  • Squassina A; National Institute of Mental Health, Klecany, Czech Republic.
  • Stein F; 3Rd Faculty of Medicine, Charles University, Prague, Czech Republic.
  • Stopkova P; Institute for Translational Psychiatry, University of Munster, Munster, Germany.
  • Streit F; Department of Psychiatric Genetics, Poznan University of Medical Sciences, Poznan, Poland.
  • Thiel K; Department of Psychiatry and Psychotherapy, University of Marburg, Marburg, Germany.
  • Thomas-Odenthal F; Center for Mind, Brain and Behavior, University of Marburg, Marburg, Germany.
Eur Arch Psychiatry Clin Neurosci ; 272(8): 1611-1620, 2022 Dec.
Article em En | MEDLINE | ID: mdl-35146571
Personality traits influence risk for suicidal behavior. We examined phenotype- and genotype-level associations between the Big Five personality traits and suicidal ideation and attempt in major depressive, bipolar and schizoaffective disorder, and schizophrenia patients (N = 3012) using fixed- and random-effects inverse variance-weighted meta-analyses. Suicidal ideations were more likely to be reported by patients with higher neuroticism and lower extraversion phenotypic scores, but showed no significant association with polygenic load for these personality traits. Our findings provide new insights into the association between personality and suicidal behavior across mental illnesses and suggest that the genetic component of personality traits is unlikely to have strong causal effects on suicidal behavior.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transtorno Depressivo Maior / Ideação Suicida Idioma: En Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Alemanha
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transtorno Depressivo Maior / Ideação Suicida Idioma: En Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Alemanha