The HDAC inhibitor GCJ-490A suppresses c-Met expression through IKK&#945; and overcomes gefitinib resistance in non-small cell lung cancer.

He, Ting; Gao, Yinglei; Fang, Yanfen; Zhang, Yangming; Zhang, Shuwei; Nan, Fajun; Ding, Jian; Chen, Yi

The HDAC inhibitor GCJ-490A suppresses c-Met expression through IKKα and overcomes gefitinib resistance in non-small cell lung cancer.

He, Ting; Gao, Yinglei; Fang, Yanfen; Zhang, Yangming; Zhang, Shuwei; Nan, Fajun; Ding, Jian; Chen, Yi.

Afiliação

He T; Division of Anti-Tumor Pharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Gao Y; University of Chinese Academy of Sciences, Beijing 100049, China.
Fang Y; Division of Anti-Tumor Pharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Zhang Y; Division of Anti-Tumor Pharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Zhang S; State Key Laboratory of Drug Research, the National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Nan F; University of Chinese Academy of Sciences, Beijing 100049, China.
Ding J; State Key Laboratory of Drug Research, the National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Chen Y; State Key Laboratory of Drug Research, the National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.

Cancer Biol Med ; 19(8)2022 02 22.

Article em En | MEDLINE | ID: mdl-35188360

Assuntos

Carcinoma Pulmonar de Células não Pequenas; Neoplasias Pulmonares; Carcinoma Pulmonar de Células não Pequenas/patologia; Linhagem Celular Tumoral; Receptores ErbB/genética; Gefitinibe/farmacologia; Gefitinibe/uso terapêutico; Inibidores de Histona Desacetilases/farmacologia; Inibidores de Histona Desacetilases/uso terapêutico; Histona Desacetilases/genética; Histona Desacetilases/metabolismo; Histonas/uso terapêutico; Humanos; Quinase I-kappa B/metabolismo; Quinase I-kappa B/uso terapêutico; Neoplasias Pulmonares/patologia; Fatores de Transcrição/metabolismo; Fatores de Transcrição/uso terapêutico

Palavras-chave

HDAC inhibitor; IKKα; NSCLC; c-Met; gefitinib

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Carcinoma Pulmonar de Células não Pequenas / Neoplasias Pulmonares Idioma: En Ano de publicação: 2022 Tipo de documento: Article País de afiliação: China

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