Modular synthesis of triazoles from 2-azidoacrylamides having a nucleophilic amino group.
Org Biomol Chem
; 20(30): 6007-6011, 2022 08 03.
Article
em En
| MEDLINE
| ID: mdl-35201255
ABSTRACT
Assembling methods using 2-azidoacrylamides having a nucleophilic amino group are disclosed. Divergent transformations of the amine-type trivalent platform were accomplished with a wide variety of electrophiles to obtain a broad range of 2-azidoacrylamides involving a fluorosulfonyl group-containing trivalent platform. Consecutive click conjugations including triazole formation, thiol-ene-type 1,4-addition, and SuFEx reactions realized the efficient assembly of easily available simple modules.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Triazóis
/
Química Click
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Japão