Assessing chemical carcinogenicity: hazard identification, classification, and risk assessment. Insight from a Toxicology Forum state-of-the-science workshop.

Felter, Susan P; Bhat, Virunya S; Botham, Philip A; Bussard, David A; Casey, Warren; Hayes, A Wallace; Hilton, Gina M; Magurany, Kelly A; Sauer, Ursula G; Ohanian, Edward V

Felter, Susan P; Bhat, Virunya S; Botham, Philip A; Bussard, David A; Casey, Warren; Hayes, A Wallace; Hilton, Gina M; Magurany, Kelly A; Sauer, Ursula G; Ohanian, Edward V.

Afiliação

Felter SP; Procter & Gamble, Mason, OH, USA.
Bhat VS; ToxStrategies, Inc., Boston, MA, USA.
Botham PA; Syngenta, Jealott's Hill, Bracknell, UK.
Bussard DA; U.S. Environmental Protection Agency, Office of the Science Advisor, Policy and Engagement, Washington, DC, USA.
Casey W; Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
Hayes AW; University of South Florida College of Public Health, Tampa, FL, USA.
Hilton GM; PETA Science Consortium International e.V., Stuttgart, Germany.
Magurany KA; NSF International, Ann Arbor, MI, USA.
Sauer UG; Scientific Consultancy - Animal Welfare, Neubiberg, Germany.
Ohanian EV; United States Environmental Protection Agency, Office of Water, Washington, DC, USA.

Crit Rev Toxicol ; 51(8): 653-694, 2021 09.

Article em En | MEDLINE | ID: mdl-35239444

Assuntos

Carcinogênese; Carcinógenos; Bioensaio; Testes de Carcinogenicidade/métodos; Carcinógenos/toxicidade; Humanos; Medição de Risco/métodos

Palavras-chave

Adverse outcome pathway (AOP); cancer bioassay (OECD TG 453); decision matrix; defined approach (DA); genotoxic carcinogenicity; hazard classification; integrated approach to testing and assessment (IATA); kinetically derived maximum dose (KMD); mode-of-action (MoA); new approach methodologies (NAM); non-genotoxic carcinogenicity; point of departure (PoD); risk assessment; rodent chronic bioassay; weight of evidence (WoE)

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Carcinógenos / Carcinogênese Idioma: En Ano de publicação: 2021 Tipo de documento: Article País de afiliação: Estados Unidos

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