Suppression of IL-12/IL-23 p40 subunit in the skin and blood of psoriasis patients by Tofacitinib is dependent on active interferon-Î³ signaling in dendritic cells: Implications for the treatment of psoriasis and interferon-driven diseases.

Vincken, Nanette L A; Welsing, Paco M J; Silva-Cardoso, Sandra C; Bekker, Cornelis P J; Lopes, Ana P; Olde Nordkamp, Michel; Leijten, Emmerik F A; Radstake, Timothy R D J; Angiolilli, Chiara

Vincken, Nanette L A; Welsing, Paco M J; Silva-Cardoso, Sandra C; Bekker, Cornelis P J; Lopes, Ana P; Olde Nordkamp, Michel; Leijten, Emmerik F A; Radstake, Timothy R D J; Angiolilli, Chiara.

Afiliação

Vincken NLA; Center for Translational Immunology, Department of Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Welsing PMJ; Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Silva-Cardoso SC; Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Bekker CPJ; Center for Translational Immunology, Department of Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Lopes AP; Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Olde Nordkamp M; Center for Translational Immunology, Department of Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Leijten EFA; Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Radstake TRDJ; Center for Translational Immunology, Department of Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Angiolilli C; Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.

Exp Dermatol ; 31(6): 962-969, 2022 06.

Article em En | MEDLINE | ID: mdl-35297512

Assuntos

Interferon gama; Subunidade p40 da Interleucina-12; Inibidores de Janus Quinases; Piperidinas; Psoríase; Pirimidinas; Pele; Artrite Psoriásica/tratamento farmacológico; Células Dendríticas/imunologia; Humanos; Interferon gama/metabolismo; Subunidade p40 da Interleucina-12/antagonistas & inibidores; Subunidade p40 da Interleucina-12/sangue; Subunidade p40 da Interleucina-12/metabolismo; Inibidores de Janus Quinases/farmacologia; Inibidores de Janus Quinases/uso terapêutico; Lipopolissacarídeos/imunologia; Piperidinas/farmacologia; Piperidinas/uso terapêutico; Psoríase/tratamento farmacológico; Pirimidinas/farmacologia; Pirimidinas/uso terapêutico; Pele/efeitos dos fármacos; Pele/imunologia

Palavras-chave

Janus Kinase Inhibitors; dendritic cells; interferon; p40; psoriasis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piperidinas / Psoríase / Pirimidinas / Pele / Interferon gama / Subunidade p40 da Interleucina-12 / Inibidores de Janus Quinases Idioma: En Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Holanda

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