Childhood cardiorespiratory fitness and the early markers of kidney disease in middle age: A population-based cohort study.
J Sci Med Sport
; 25(6): 499-504, 2022 Jun.
Article
em En
| MEDLINE
| ID: mdl-35379579
ABSTRACT
OBJECTIVES:
To investigate the relationship of childhood cardiorespiratory fitness with early markers of chronic kidney disease, glomerular hyperfiltration and albuminuria, in midlife.DESIGN:
Prospective cohort study.METHODS:
This study included 1371 participants aged 36-49â¯years who participated in the 1985 Australian Schools Health and Fitness Survey when they were 7-15â¯years of age. Childhood cardiorespiratory fitness was estimated by the time taken to complete a 1.6-â¯km run. Blood and urine samples were collected at follow-up. Log-binomial regression was used to determine the associations of childhood cardiorespiratory fitness with glomerular hyperfiltration [estimated glomerular filtration rate (mL/min/1.73â¯m2)â¯>â¯95th percentile standardized for age and sex] and albuminuria (urine albumin-to-creatinine ratioâ¯≥â¯2.5â¯mg/mmol in males or ≥3.5â¯mg/mmol in females) in midlife.RESULTS:
Compared with women with high childhood cardiorespiratory fitness, those with lower childhood cardiorespiratory fitness had a higher risk of glomerular hyperfiltration in midlife after adjusting for childhood age, the duration of follow-up, and midlife smoking status [adjusted relative riskâ¯=â¯2.86, 95% confidence interval, 1.04-7.86 for individuals with moderate childhood cardiorespiratory fitness (Pâ¯=â¯0.04), and adjusted relative riskâ¯=â¯3.38, 95% confidence interval, 1.13-10.14 for individuals with low childhood cardiorespiratory fitness (Pâ¯=â¯0.03)]. Further adjustment for childhood and midlife body mass index resulted in a slightly attenuated and statistically non-significant association. No significant associations were found with glomerular hyperfiltration in males or albuminuria in either males or females.CONCLUSIONS:
Low cardiorespiratory fitness in childhood may increase the risk of glomerular hyperfiltration in midlife in females, possibly via a path through adult cardiorespiratory fitness.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Insuficiência Renal Crônica
/
Aptidão Cardiorrespiratória
País/Região como assunto:
Oceania
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Austrália