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MRI Radiogenomics of Pediatric Medulloblastoma: A Multicenter Study.
Zhang, Michael; Wong, Samuel W; Wright, Jason N; Wagner, Matthias W; Toescu, Sebastian; Han, Michelle; Tam, Lydia T; Zhou, Quan; Ahmadian, Saman S; Shpanskaya, Katie; Lummus, Seth; Lai, Hollie; Eghbal, Azam; Radmanesh, Alireza; Nemelka, Jordan; Harward, Stephen; Malinzak, Michael; Laughlin, Suzanne; Perreault, Sébastien; Braun, Kristina R M; Lober, Robert M; Cho, Yoon Jae; Ertl-Wagner, Birgit; Ho, Chang Y; Mankad, Kshitij; Vogel, Hannes; Cheshier, Samuel H; Jacques, Thomas S; Aquilina, Kristian; Fisher, Paul G; Taylor, Michael; Poussaint, Tina; Vitanza, Nicholas A; Grant, Gerald A; Pfister, Stefan; Thompson, Eric; Jaju, Alok; Ramaswamy, Vijay; Yeom, Kristen W.
Afiliação
  • Zhang M; From the Departments of Neurosurgery (M.Z., Q.Z.), Otolaryngology-Head and Neck Surgery (Q.Z.), and Pathology (S.S.A., H.V.), Stanford Hospital and Clinics, Stanford, Calif; Departments of Radiology (M.Z., K.W.Y.), Neurology (P.G.F.), and Neurosurgery (G.A.G.), Lucile Packard Children's Hospital, St
  • Wong SW; From the Departments of Neurosurgery (M.Z., Q.Z.), Otolaryngology-Head and Neck Surgery (Q.Z.), and Pathology (S.S.A., H.V.), Stanford Hospital and Clinics, Stanford, Calif; Departments of Radiology (M.Z., K.W.Y.), Neurology (P.G.F.), and Neurosurgery (G.A.G.), Lucile Packard Children's Hospital, St
  • Wright JN; From the Departments of Neurosurgery (M.Z., Q.Z.), Otolaryngology-Head and Neck Surgery (Q.Z.), and Pathology (S.S.A., H.V.), Stanford Hospital and Clinics, Stanford, Calif; Departments of Radiology (M.Z., K.W.Y.), Neurology (P.G.F.), and Neurosurgery (G.A.G.), Lucile Packard Children's Hospital, St
  • Wagner MW; From the Departments of Neurosurgery (M.Z., Q.Z.), Otolaryngology-Head and Neck Surgery (Q.Z.), and Pathology (S.S.A., H.V.), Stanford Hospital and Clinics, Stanford, Calif; Departments of Radiology (M.Z., K.W.Y.), Neurology (P.G.F.), and Neurosurgery (G.A.G.), Lucile Packard Children's Hospital, St
  • Toescu S; From the Departments of Neurosurgery (M.Z., Q.Z.), Otolaryngology-Head and Neck Surgery (Q.Z.), and Pathology (S.S.A., H.V.), Stanford Hospital and Clinics, Stanford, Calif; Departments of Radiology (M.Z., K.W.Y.), Neurology (P.G.F.), and Neurosurgery (G.A.G.), Lucile Packard Children's Hospital, St
  • Han M; From the Departments of Neurosurgery (M.Z., Q.Z.), Otolaryngology-Head and Neck Surgery (Q.Z.), and Pathology (S.S.A., H.V.), Stanford Hospital and Clinics, Stanford, Calif; Departments of Radiology (M.Z., K.W.Y.), Neurology (P.G.F.), and Neurosurgery (G.A.G.), Lucile Packard Children's Hospital, St
  • Tam LT; From the Departments of Neurosurgery (M.Z., Q.Z.), Otolaryngology-Head and Neck Surgery (Q.Z.), and Pathology (S.S.A., H.V.), Stanford Hospital and Clinics, Stanford, Calif; Departments of Radiology (M.Z., K.W.Y.), Neurology (P.G.F.), and Neurosurgery (G.A.G.), Lucile Packard Children's Hospital, St
  • Zhou Q; From the Departments of Neurosurgery (M.Z., Q.Z.), Otolaryngology-Head and Neck Surgery (Q.Z.), and Pathology (S.S.A., H.V.), Stanford Hospital and Clinics, Stanford, Calif; Departments of Radiology (M.Z., K.W.Y.), Neurology (P.G.F.), and Neurosurgery (G.A.G.), Lucile Packard Children's Hospital, St
  • Ahmadian SS; From the Departments of Neurosurgery (M.Z., Q.Z.), Otolaryngology-Head and Neck Surgery (Q.Z.), and Pathology (S.S.A., H.V.), Stanford Hospital and Clinics, Stanford, Calif; Departments of Radiology (M.Z., K.W.Y.), Neurology (P.G.F.), and Neurosurgery (G.A.G.), Lucile Packard Children's Hospital, St
  • Shpanskaya K; From the Departments of Neurosurgery (M.Z., Q.Z.), Otolaryngology-Head and Neck Surgery (Q.Z.), and Pathology (S.S.A., H.V.), Stanford Hospital and Clinics, Stanford, Calif; Departments of Radiology (M.Z., K.W.Y.), Neurology (P.G.F.), and Neurosurgery (G.A.G.), Lucile Packard Children's Hospital, St
  • Lummus S; From the Departments of Neurosurgery (M.Z., Q.Z.), Otolaryngology-Head and Neck Surgery (Q.Z.), and Pathology (S.S.A., H.V.), Stanford Hospital and Clinics, Stanford, Calif; Departments of Radiology (M.Z., K.W.Y.), Neurology (P.G.F.), and Neurosurgery (G.A.G.), Lucile Packard Children's Hospital, St
  • Lai H; From the Departments of Neurosurgery (M.Z., Q.Z.), Otolaryngology-Head and Neck Surgery (Q.Z.), and Pathology (S.S.A., H.V.), Stanford Hospital and Clinics, Stanford, Calif; Departments of Radiology (M.Z., K.W.Y.), Neurology (P.G.F.), and Neurosurgery (G.A.G.), Lucile Packard Children's Hospital, St
  • Eghbal A; From the Departments of Neurosurgery (M.Z., Q.Z.), Otolaryngology-Head and Neck Surgery (Q.Z.), and Pathology (S.S.A., H.V.), Stanford Hospital and Clinics, Stanford, Calif; Departments of Radiology (M.Z., K.W.Y.), Neurology (P.G.F.), and Neurosurgery (G.A.G.), Lucile Packard Children's Hospital, St
  • Radmanesh A; From the Departments of Neurosurgery (M.Z., Q.Z.), Otolaryngology-Head and Neck Surgery (Q.Z.), and Pathology (S.S.A., H.V.), Stanford Hospital and Clinics, Stanford, Calif; Departments of Radiology (M.Z., K.W.Y.), Neurology (P.G.F.), and Neurosurgery (G.A.G.), Lucile Packard Children's Hospital, St
  • Nemelka J; From the Departments of Neurosurgery (M.Z., Q.Z.), Otolaryngology-Head and Neck Surgery (Q.Z.), and Pathology (S.S.A., H.V.), Stanford Hospital and Clinics, Stanford, Calif; Departments of Radiology (M.Z., K.W.Y.), Neurology (P.G.F.), and Neurosurgery (G.A.G.), Lucile Packard Children's Hospital, St
  • Harward S; From the Departments of Neurosurgery (M.Z., Q.Z.), Otolaryngology-Head and Neck Surgery (Q.Z.), and Pathology (S.S.A., H.V.), Stanford Hospital and Clinics, Stanford, Calif; Departments of Radiology (M.Z., K.W.Y.), Neurology (P.G.F.), and Neurosurgery (G.A.G.), Lucile Packard Children's Hospital, St
  • Malinzak M; From the Departments of Neurosurgery (M.Z., Q.Z.), Otolaryngology-Head and Neck Surgery (Q.Z.), and Pathology (S.S.A., H.V.), Stanford Hospital and Clinics, Stanford, Calif; Departments of Radiology (M.Z., K.W.Y.), Neurology (P.G.F.), and Neurosurgery (G.A.G.), Lucile Packard Children's Hospital, St
  • Laughlin S; From the Departments of Neurosurgery (M.Z., Q.Z.), Otolaryngology-Head and Neck Surgery (Q.Z.), and Pathology (S.S.A., H.V.), Stanford Hospital and Clinics, Stanford, Calif; Departments of Radiology (M.Z., K.W.Y.), Neurology (P.G.F.), and Neurosurgery (G.A.G.), Lucile Packard Children's Hospital, St
  • Perreault S; From the Departments of Neurosurgery (M.Z., Q.Z.), Otolaryngology-Head and Neck Surgery (Q.Z.), and Pathology (S.S.A., H.V.), Stanford Hospital and Clinics, Stanford, Calif; Departments of Radiology (M.Z., K.W.Y.), Neurology (P.G.F.), and Neurosurgery (G.A.G.), Lucile Packard Children's Hospital, St
  • Braun KRM; From the Departments of Neurosurgery (M.Z., Q.Z.), Otolaryngology-Head and Neck Surgery (Q.Z.), and Pathology (S.S.A., H.V.), Stanford Hospital and Clinics, Stanford, Calif; Departments of Radiology (M.Z., K.W.Y.), Neurology (P.G.F.), and Neurosurgery (G.A.G.), Lucile Packard Children's Hospital, St
  • Lober RM; From the Departments of Neurosurgery (M.Z., Q.Z.), Otolaryngology-Head and Neck Surgery (Q.Z.), and Pathology (S.S.A., H.V.), Stanford Hospital and Clinics, Stanford, Calif; Departments of Radiology (M.Z., K.W.Y.), Neurology (P.G.F.), and Neurosurgery (G.A.G.), Lucile Packard Children's Hospital, St
  • Cho YJ; From the Departments of Neurosurgery (M.Z., Q.Z.), Otolaryngology-Head and Neck Surgery (Q.Z.), and Pathology (S.S.A., H.V.), Stanford Hospital and Clinics, Stanford, Calif; Departments of Radiology (M.Z., K.W.Y.), Neurology (P.G.F.), and Neurosurgery (G.A.G.), Lucile Packard Children's Hospital, St
  • Ertl-Wagner B; From the Departments of Neurosurgery (M.Z., Q.Z.), Otolaryngology-Head and Neck Surgery (Q.Z.), and Pathology (S.S.A., H.V.), Stanford Hospital and Clinics, Stanford, Calif; Departments of Radiology (M.Z., K.W.Y.), Neurology (P.G.F.), and Neurosurgery (G.A.G.), Lucile Packard Children's Hospital, St
  • Ho CY; From the Departments of Neurosurgery (M.Z., Q.Z.), Otolaryngology-Head and Neck Surgery (Q.Z.), and Pathology (S.S.A., H.V.), Stanford Hospital and Clinics, Stanford, Calif; Departments of Radiology (M.Z., K.W.Y.), Neurology (P.G.F.), and Neurosurgery (G.A.G.), Lucile Packard Children's Hospital, St
  • Mankad K; From the Departments of Neurosurgery (M.Z., Q.Z.), Otolaryngology-Head and Neck Surgery (Q.Z.), and Pathology (S.S.A., H.V.), Stanford Hospital and Clinics, Stanford, Calif; Departments of Radiology (M.Z., K.W.Y.), Neurology (P.G.F.), and Neurosurgery (G.A.G.), Lucile Packard Children's Hospital, St
  • Vogel H; From the Departments of Neurosurgery (M.Z., Q.Z.), Otolaryngology-Head and Neck Surgery (Q.Z.), and Pathology (S.S.A., H.V.), Stanford Hospital and Clinics, Stanford, Calif; Departments of Radiology (M.Z., K.W.Y.), Neurology (P.G.F.), and Neurosurgery (G.A.G.), Lucile Packard Children's Hospital, St
  • Cheshier SH; From the Departments of Neurosurgery (M.Z., Q.Z.), Otolaryngology-Head and Neck Surgery (Q.Z.), and Pathology (S.S.A., H.V.), Stanford Hospital and Clinics, Stanford, Calif; Departments of Radiology (M.Z., K.W.Y.), Neurology (P.G.F.), and Neurosurgery (G.A.G.), Lucile Packard Children's Hospital, St
  • Jacques TS; From the Departments of Neurosurgery (M.Z., Q.Z.), Otolaryngology-Head and Neck Surgery (Q.Z.), and Pathology (S.S.A., H.V.), Stanford Hospital and Clinics, Stanford, Calif; Departments of Radiology (M.Z., K.W.Y.), Neurology (P.G.F.), and Neurosurgery (G.A.G.), Lucile Packard Children's Hospital, St
  • Aquilina K; From the Departments of Neurosurgery (M.Z., Q.Z.), Otolaryngology-Head and Neck Surgery (Q.Z.), and Pathology (S.S.A., H.V.), Stanford Hospital and Clinics, Stanford, Calif; Departments of Radiology (M.Z., K.W.Y.), Neurology (P.G.F.), and Neurosurgery (G.A.G.), Lucile Packard Children's Hospital, St
  • Fisher PG; From the Departments of Neurosurgery (M.Z., Q.Z.), Otolaryngology-Head and Neck Surgery (Q.Z.), and Pathology (S.S.A., H.V.), Stanford Hospital and Clinics, Stanford, Calif; Departments of Radiology (M.Z., K.W.Y.), Neurology (P.G.F.), and Neurosurgery (G.A.G.), Lucile Packard Children's Hospital, St
  • Taylor M; From the Departments of Neurosurgery (M.Z., Q.Z.), Otolaryngology-Head and Neck Surgery (Q.Z.), and Pathology (S.S.A., H.V.), Stanford Hospital and Clinics, Stanford, Calif; Departments of Radiology (M.Z., K.W.Y.), Neurology (P.G.F.), and Neurosurgery (G.A.G.), Lucile Packard Children's Hospital, St
  • Poussaint T; From the Departments of Neurosurgery (M.Z., Q.Z.), Otolaryngology-Head and Neck Surgery (Q.Z.), and Pathology (S.S.A., H.V.), Stanford Hospital and Clinics, Stanford, Calif; Departments of Radiology (M.Z., K.W.Y.), Neurology (P.G.F.), and Neurosurgery (G.A.G.), Lucile Packard Children's Hospital, St
  • Vitanza NA; From the Departments of Neurosurgery (M.Z., Q.Z.), Otolaryngology-Head and Neck Surgery (Q.Z.), and Pathology (S.S.A., H.V.), Stanford Hospital and Clinics, Stanford, Calif; Departments of Radiology (M.Z., K.W.Y.), Neurology (P.G.F.), and Neurosurgery (G.A.G.), Lucile Packard Children's Hospital, St
  • Grant GA; From the Departments of Neurosurgery (M.Z., Q.Z.), Otolaryngology-Head and Neck Surgery (Q.Z.), and Pathology (S.S.A., H.V.), Stanford Hospital and Clinics, Stanford, Calif; Departments of Radiology (M.Z., K.W.Y.), Neurology (P.G.F.), and Neurosurgery (G.A.G.), Lucile Packard Children's Hospital, St
  • Pfister S; From the Departments of Neurosurgery (M.Z., Q.Z.), Otolaryngology-Head and Neck Surgery (Q.Z.), and Pathology (S.S.A., H.V.), Stanford Hospital and Clinics, Stanford, Calif; Departments of Radiology (M.Z., K.W.Y.), Neurology (P.G.F.), and Neurosurgery (G.A.G.), Lucile Packard Children's Hospital, St
  • Thompson E; From the Departments of Neurosurgery (M.Z., Q.Z.), Otolaryngology-Head and Neck Surgery (Q.Z.), and Pathology (S.S.A., H.V.), Stanford Hospital and Clinics, Stanford, Calif; Departments of Radiology (M.Z., K.W.Y.), Neurology (P.G.F.), and Neurosurgery (G.A.G.), Lucile Packard Children's Hospital, St
  • Jaju A; From the Departments of Neurosurgery (M.Z., Q.Z.), Otolaryngology-Head and Neck Surgery (Q.Z.), and Pathology (S.S.A., H.V.), Stanford Hospital and Clinics, Stanford, Calif; Departments of Radiology (M.Z., K.W.Y.), Neurology (P.G.F.), and Neurosurgery (G.A.G.), Lucile Packard Children's Hospital, St
  • Ramaswamy V; From the Departments of Neurosurgery (M.Z., Q.Z.), Otolaryngology-Head and Neck Surgery (Q.Z.), and Pathology (S.S.A., H.V.), Stanford Hospital and Clinics, Stanford, Calif; Departments of Radiology (M.Z., K.W.Y.), Neurology (P.G.F.), and Neurosurgery (G.A.G.), Lucile Packard Children's Hospital, St
  • Yeom KW; From the Departments of Neurosurgery (M.Z., Q.Z.), Otolaryngology-Head and Neck Surgery (Q.Z.), and Pathology (S.S.A., H.V.), Stanford Hospital and Clinics, Stanford, Calif; Departments of Radiology (M.Z., K.W.Y.), Neurology (P.G.F.), and Neurosurgery (G.A.G.), Lucile Packard Children's Hospital, St
Radiology ; 304(2): 406-416, 2022 08.
Article em En | MEDLINE | ID: mdl-35438562
ABSTRACT
Background Radiogenomics of pediatric medulloblastoma (MB) offers an opportunity for MB risk stratification, which may aid therapeutic decision making, family counseling, and selection of patient groups suitable for targeted genetic analysis. Purpose To develop machine learning strategies that identify the four clinically significant MB molecular subgroups. Materials and Methods In this retrospective study, consecutive pediatric patients with newly diagnosed MB at MRI at 12 international pediatric sites between July 1997 and May 2020 were identified. There were 1800 features extracted from T2- and contrast-enhanced T1-weighted preoperative MRI scans. A two-stage sequential classifier was designed-one that first identifies non-wingless (WNT) and non-sonic hedgehog (SHH) MB and then differentiates therapeutically relevant WNT from SHH. Further, a classifier that distinguishes high-risk group 3 from group 4 MB was developed. An independent, binary subgroup analysis was conducted to uncover radiomics features unique to infantile versus childhood SHH subgroups. The best-performing models from six candidate classifiers were selected, and performance was measured on holdout test sets. CIs were obtained by bootstrapping the test sets for 2000 random samples. Model accuracy score was compared with the no-information rate using the Wald test. Results The study cohort comprised 263 patients (mean age ± SD at diagnosis, 87 months ± 60; 166 boys). A two-stage classifier outperformed a single-stage multiclass classifier. The combined, sequential classifier achieved a microaveraged F1 score of 88% and a binary F1 score of 95% specifically for WNT. A group 3 versus group 4 classifier achieved an area under the receiver operating characteristic curve of 98%. Of the Image Biomarker Standardization Initiative features, texture and first-order intensity features were most contributory across the molecular subgroups. Conclusion An MRI-based machine learning decision path allowed identification of the four clinically relevant molecular pediatric medulloblastoma subgroups. © RSNA, 2022 Online supplemental material is available for this article. See also the editorial by Chaudhary and Bapuraj in this issue.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Cerebelares / Meduloblastoma Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Cerebelares / Meduloblastoma Idioma: En Ano de publicação: 2022 Tipo de documento: Article