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Using Mendelian randomisation to identify opportunities for type 2 diabetes prevention by repurposing medications used for lipid management.
Khankari, Nikhil K; Keaton, Jacob M; Walker, Venexia M; Lee, Kyung Min; Shuey, Megan M; Clarke, Shoa L; Heberer, Kent R; Miller, Donald R; Reaven, Peter D; Lynch, Julie A; Vujkovic, Marijana; Edwards, Todd L.
Afiliação
  • Khankari NK; Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, 2525 West End Ave, Suite 700, Nashville, TN 37203, USA. Electronic address: nikhil.khankari@vumc.org.
  • Keaton JM; Medical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA; Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Walker VM; Medical Research Council, Integrative Epidemiology Unit, University of Bristol, Bristol, UK; Bristol Medical School: Population Health Sciences, University of Bristol, Bristol, UK; Department of Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
  • Lee KM; VA Informatics and Computing Infrastructure, VA Salt Lake City Health Care System, Salt Lake City, UT, USA.
  • Shuey MM; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, 2525 West End Ave, Suite 700, Nashville, TN 37203, USA.
  • Clarke SL; Departments of Medicine and Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.
  • Heberer KR; VA Palo Alto Health Care System, Palo Alto, CA, USA; Departments of Medicine and Endocrinology, Stanford University School of Medicine, Stanford, CA, USA.
  • Miller DR; Center for Healthcare Organization and Implementation Research, Bedford VA Healthcare System, Bedford, MA, USA; Center for Population Health, Department of Biomedical and Nutritional Sciences, University of Massachusetts, Lowell, MA, USA.
  • Reaven PD; Phoenix VA Health Care Center, Phoenix, AZ, USA; College of Medicine, University of Arizona, Phoenix, AZ, USA.
  • Lynch JA; VA Informatics and Computing Infrastructure, VA Salt Lake City Health Care System, Salt Lake City, UT, USA; College of Nursing and Health Sciences, University of Massachusetts, Lowell, MA, USA.
  • Vujkovic M; Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.
  • Edwards TL; Vanderbilt Genetics Institute, Vanderbilt University Medical Center, 2525 West End Ave, Suite 700, Nashville, TN 37203, USA; Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA; Nashville VA Medical Center, Nashville, TN, USA. Electronic address
EBioMedicine ; 80: 104038, 2022 Jun.
Article em En | MEDLINE | ID: mdl-35500537
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Inibidores de Hidroximetilglutaril-CoA Redutases / Diabetes Mellitus Tipo 2 Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Inibidores de Hidroximetilglutaril-CoA Redutases / Diabetes Mellitus Tipo 2 Idioma: En Ano de publicação: 2022 Tipo de documento: Article