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Health Outcomes of 215 Mothers of Children With Autoimmune Congenital Heart Block: Analysis of the French Neonatal Lupus Syndrome Registry.
Miniaoui, Imene; Morel, Nathalie; Lévesque, Kateri; Maltret, Alice; Driessen, Marine; Masseau, Agathe; Orquevaux, Pauline; Piette, Jean-Charles; Barriere, Francois; Le Bidois, Jérome; Georgin-Lavialle, Sophie; Guettrot-Imbert, Gaëlle; Le Guern, Véronique; Mouthon, Luc; Jallouli, Moez; Deligny, Christophe; Hachulla, Eric; Romefort, Bénédicte; Bonnet, Damien; Costedoat-Chalumeau, Nathalie.
Afiliação
  • Miniaoui I; I. Miniaoui, MD, N. Morel, MD, K. Lévesque, MD, G. Guettrot-Imbert, MD, V. Le Guern, MD, L. Mouthon, MD, PhD, M. Jallouli, MD, AP-HP, Hôpital Cochin, Centre de référence maladies auto-immunes et systémiques rares d'Ile de France, Paris.
  • Morel N; I. Miniaoui, MD, N. Morel, MD, K. Lévesque, MD, G. Guettrot-Imbert, MD, V. Le Guern, MD, L. Mouthon, MD, PhD, M. Jallouli, MD, AP-HP, Hôpital Cochin, Centre de référence maladies auto-immunes et systémiques rares d'Ile de France, Paris.
  • Lévesque K; I. Miniaoui, MD, N. Morel, MD, K. Lévesque, MD, G. Guettrot-Imbert, MD, V. Le Guern, MD, L. Mouthon, MD, PhD, M. Jallouli, MD, AP-HP, Hôpital Cochin, Centre de référence maladies auto-immunes et systémiques rares d'Ile de France, Paris.
  • Maltret A; A. Maltret, MD, J. Le Bidois, MD, D. Bonnet, MD, PhD, AP-HP, Centre de référence Malformations Cardiaques Congénitales Complexes - M3C, Hôpital Necker-Enfants malades, Université de Paris, Paris.
  • Driessen M; M. Driessen, MD, Obstetrics and materno-fœtal unit, AP-HP Hôpital Necker-Enfant Malades, Université de Paris, Paris.
  • Masseau A; A. Masseau, MD, Service de Médecine Interne, CHU Nantes.
  • Orquevaux P; P. Orquevaux, MD, CHU de Reims, Centre de compétence maladies auto-immunes et systémiques rares, Reims.
  • Piette JC; J.C. Piette, MD, PhD, Université Pierre et Marie Curie, AP-HP, Hôpital Pitié-Salpêtrière, Centre de référence maladies auto-immunes et systémiques rares, Paris.
  • Barriere F; F. Barriere, MD, AP-HM, Hôpital Timone Enfants, Unité de Réanimation Pédiatrique, Marseille.
  • Le Bidois J; A. Maltret, MD, J. Le Bidois, MD, D. Bonnet, MD, PhD, AP-HP, Centre de référence Malformations Cardiaques Congénitales Complexes - M3C, Hôpital Necker-Enfants malades, Université de Paris, Paris.
  • Georgin-Lavialle S; S. Georgin-Lavialle, MD, PhD, AP-HP, Hôpital Tenon, Paris.
  • Guettrot-Imbert G; I. Miniaoui, MD, N. Morel, MD, K. Lévesque, MD, G. Guettrot-Imbert, MD, V. Le Guern, MD, L. Mouthon, MD, PhD, M. Jallouli, MD, AP-HP, Hôpital Cochin, Centre de référence maladies auto-immunes et systémiques rares d'Ile de France, Paris.
  • Le Guern V; I. Miniaoui, MD, N. Morel, MD, K. Lévesque, MD, G. Guettrot-Imbert, MD, V. Le Guern, MD, L. Mouthon, MD, PhD, M. Jallouli, MD, AP-HP, Hôpital Cochin, Centre de référence maladies auto-immunes et systémiques rares d'Ile de France, Paris.
  • Mouthon L; I. Miniaoui, MD, N. Morel, MD, K. Lévesque, MD, G. Guettrot-Imbert, MD, V. Le Guern, MD, L. Mouthon, MD, PhD, M. Jallouli, MD, AP-HP, Hôpital Cochin, Centre de référence maladies auto-immunes et systémiques rares d'Ile de France, Paris.
  • Jallouli M; I. Miniaoui, MD, N. Morel, MD, K. Lévesque, MD, G. Guettrot-Imbert, MD, V. Le Guern, MD, L. Mouthon, MD, PhD, M. Jallouli, MD, AP-HP, Hôpital Cochin, Centre de référence maladies auto-immunes et systémiques rares d'Ile de France, Paris.
  • Deligny C; C. Deligny, MD, CHU Fort de France, Martinique.
  • Hachulla E; E. Hachulla, MD, PhD, Université Lille, Inserm, CHU Lille, Service de Médecine Interne et Immunologie Clinique, Centre de référence des maladies auto-immunes systémiques rares du Nord et Nord-Ouest de France (CeRAINO), and U1286 - INFINITE - Institute for Translational Research in Inflammation, Lill
  • Romefort B; B. Romefort, Cardiopédiatrie, CHU de Nantes.
  • Bonnet D; A. Maltret, MD, J. Le Bidois, MD, D. Bonnet, MD, PhD, AP-HP, Centre de référence Malformations Cardiaques Congénitales Complexes - M3C, Hôpital Necker-Enfants malades, Université de Paris, Paris.
  • Costedoat-Chalumeau N; N. Costedoat-Chalumeau, MD, PhD, AP-HP, Hôpital Cochin, Centre de référence maladies auto-immunes et systémiques rares d'Ile de France, and Université Paris Descartes-Sorbonne Paris Cité, and INSERM U 1153, Center for Epidemiology and Statistics Sorbonne Paris Cité (CRESS), Paris, France. nathalie.c
J Rheumatol ; 49(10): 1124-1130, 2022 Oct.
Article em En | MEDLINE | ID: mdl-35501147
ABSTRACT

OBJECTIVE:

Transplacental passage of maternal anti-SSA and anti-SSB antibodies, potentially associated with maternal autoimmune diseases, can cause neonatal lupus syndrome. Given the paucity of data in this setting, we report short- and long-term outcomes of mothers of offspring with congenital heart block (CHB).

METHODS:

This retrospective study included anti-SSA/SSB antibody-positive mothers of fetuses with high-degree CHB and focused on their health status before pregnancy, at CHB diagnosis, and thereafter.

RESULTS:

We analyzed 215 women with at least 1 pregnancy with CHB. Prior to this diagnosis, only 52 (24%) mothers had been diagnosed with an autoimmune disease, mainly systemic lupus erythematosus (SLE; n = 26, 12%) and Sjögren syndrome (SS; n = 16, 7%). Six more were diagnosed with an autoimmune disease during the index pregnancy. Of the 157 mothers (73%) with no such diagnosis at childbirth, 77 (49%) developed one after a median follow-up of 11 years (range 21 days to 54 years). By the end of follow-up, 135 women (63%) had an autoimmune disease diagnosis, mainly SLE (n = 54, 25%) and SS (n = 72, 33%). Three patients with SLE had renal involvement, and only 6 (3%) had required an immunosuppressive drug at any point. The symptoms best predicting autoimmune disease development were arthralgia and myalgia (P < 0.001), dry syndrome (P = 0.01), and parotid swelling (P = 0.05).

CONCLUSION:

One-quarter of the patients had an autoimmune disease diagnosis at the time of the fetal CHB diagnosis. Nearly half of those without an initial diagnosis progressed during follow-up, most without severe manifestations. Severe diseases such as lupus nephritis were rarely seen, and immunosuppressive drugs were rarely required.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doenças Autoimunes / Lúpus Eritematoso Sistêmico Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doenças Autoimunes / Lúpus Eritematoso Sistêmico Idioma: En Ano de publicação: 2022 Tipo de documento: Article