Association between visual emphysema and lung nodules on low-dose CT scan in a Chinese Lung Cancer Screening Program (Nelcin-B3).
Eur Radiol
; 32(12): 8162-8170, 2022 Dec.
Article
em En
| MEDLINE
| ID: mdl-35678862
ABSTRACT
OBJECTIVES:
This study aimed to evaluate the association between visual emphysema and the presence of lung nodules, and Lung-RADS category with low-dose CT (LDCT).METHODS:
Baseline LDCT scans of 1162 participants from a lung cancer screening study (Nelcin-B3) performed in a Chinese general population were included. The presence, subtypes, and severity of emphysema (at least trace) were visually assessed by one radiologist. The presence, size, and classification of non-calcified lung nodules (≥ 30 mm3) and Lung-RADS category were independently assessed by another two radiologists. Multivariable logistic regression and stratified analyses were performed to estimate the association between emphysema and lung nodules, Lung-RADS category, after adjusting for age, sex, BMI, smoking status, pack-years, and passive smoking.RESULTS:
Emphysema and lung nodules were observed in 674 (58.0%) and 424 (36.5%) participants, respectively. Participants with emphysema had a 71% increased risk of having lung nodules (adjusted odds ratios, aOR 1.71, 95% CI 1.26-2.31) and 70% increased risk of positive Lung-RADS category (aOR 1.70, 95% CI 1.09-2.66) than those without emphysema. Participants with paraseptal emphysema (n = 47, 4.0%) were at a higher risk for lung nodules than those with centrilobular emphysema (CLE) (aOR 2.43, 95% CI 1.32-4.50 and aOR 1.60, 95% CI 1.23-2.09, respectively). Only CLE was associated with positive Lung-RADS category (p = 0.02). CLE severity was related to a higher risk of lung nodules (ranges aOR 1.44-2.61, overall p < 0.01).CONCLUSION:
In a Chinese general population, visual emphysema based on LDCT is independently related to the presence of lung nodules (≥ 30 mm3) and specifically CLE subtype is related to positive Lung-RADS category. The risk of lung nodules increases with CLE severity. KEY POINTS ⢠Participants with emphysema had an increased risk of having lung nodules, especially smokers. ⢠Participants with PSE were at a higher risk for lung nodules than those with CLE, but nodules in participants with CLE had a higher risk of positive Lung-RADS category. ⢠The risk of lung nodules increases with CLE severity.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Lesões Pré-Cancerosas
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Enfisema Pulmonar
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Enfisema
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Neoplasias Pulmonares
País/Região como assunto:
Asia
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
Holanda