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Reengineering the specificity of the highly selective Clostridium botulinum protease via directed evolution.
Dyer, Rebekah P; Isoda, Hariny M; Salcedo, Gabriela S; Speciale, Gaetano; Fletcher, Madison H; Le, Linh Q; Liu, Yi; Brami-Cherrier, Karen; Malik, Shiazah Z; Vazquez-Cintron, Edwin J; Chu, Andrew C; Rupp, David C; Jacky, Birgitte P S; Nguyen, Thu T M; Katz, Benjamin B; Steward, Lance E; Majumdar, Sudipta; Brideau-Andersen, Amy D; Weiss, Gregory A.
Afiliação
  • Dyer RP; Molecular Biology and Biochemistry, University of California, Irvine, 1102 NS-2, Irvine, CA, 92697-2025, USA.
  • Isoda HM; Departments of Chemistry, University of California, Irvine, 1102 NS-2, Irvine, CA, 92697-2025, USA.
  • Salcedo GS; Molecular Biology and Biochemistry, University of California, Irvine, 1102 NS-2, Irvine, CA, 92697-2025, USA.
  • Speciale G; Departments of Chemistry, University of California, Irvine, 1102 NS-2, Irvine, CA, 92697-2025, USA.
  • Fletcher MH; Departments of Chemistry, University of California, Irvine, 1102 NS-2, Irvine, CA, 92697-2025, USA.
  • Le LQ; Allergan Aesthetics, An AbbVie company, 2525 Dupont Drive, Irvine, CA, 92612, USA.
  • Liu Y; Allergan Aesthetics, An AbbVie company, 2525 Dupont Drive, Irvine, CA, 92612, USA.
  • Brami-Cherrier K; Allergan Aesthetics, An AbbVie company, 2525 Dupont Drive, Irvine, CA, 92612, USA.
  • Malik SZ; Allergan Aesthetics, An AbbVie company, 2525 Dupont Drive, Irvine, CA, 92612, USA.
  • Vazquez-Cintron EJ; Allergan Aesthetics, An AbbVie company, 2525 Dupont Drive, Irvine, CA, 92612, USA.
  • Chu AC; Molecular Biology and Biochemistry, University of California, Irvine, 1102 NS-2, Irvine, CA, 92697-2025, USA.
  • Rupp DC; Allergan Aesthetics, An AbbVie company, 2525 Dupont Drive, Irvine, CA, 92612, USA.
  • Jacky BPS; Allergan Aesthetics, An AbbVie company, 2525 Dupont Drive, Irvine, CA, 92612, USA.
  • Nguyen TTM; Departments of Chemistry, University of California, Irvine, 1102 NS-2, Irvine, CA, 92697-2025, USA.
  • Katz BB; Departments of Chemistry, University of California, Irvine, 1102 NS-2, Irvine, CA, 92697-2025, USA.
  • Steward LE; Allergan Aesthetics, An AbbVie company, 2525 Dupont Drive, Irvine, CA, 92612, USA.
  • Majumdar S; Departments of Chemistry, University of California, Irvine, 1102 NS-2, Irvine, CA, 92697-2025, USA.
  • Brideau-Andersen AD; Allergan Aesthetics, An AbbVie company, 2525 Dupont Drive, Irvine, CA, 92612, USA. amy.brideauandersen@abbvie.com.
  • Weiss GA; Departments of Chemistry, University of California, Irvine, 1102 NS-2, Irvine, CA, 92697-2025, USA. gweiss@uci.edu.
Sci Rep ; 12(1): 9956, 2022 06 15.
Article em En | MEDLINE | ID: mdl-35705606
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peptídeo Hidrolases / Engenharia de Proteínas / Clostridium botulinum / Toxinas Botulínicas Tipo A Idioma: En Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peptídeo Hidrolases / Engenharia de Proteínas / Clostridium botulinum / Toxinas Botulínicas Tipo A Idioma: En Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos