Synthesis of dihydrofuran-3-one and 9,10-phenanthrenequinone hybrid molecules and biological evaluation against colon cancer cells as selective Akt kinase inhibitors.

Huang, Jingjing; Chen, Yufei; Guo, Yinfeng; Bao, Ming; Hong, Kemiao; Zhang, Yuanqing; Hu, Wenhao; Lei, Jinping; Liu, Yongqiang; Xu, Xinfang

Huang, Jingjing; Chen, Yufei; Guo, Yinfeng; Bao, Ming; Hong, Kemiao; Zhang, Yuanqing; Hu, Wenhao; Lei, Jinping; Liu, Yongqiang; Xu, Xinfang.

Afiliação

Huang J; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.
Chen Y; Research Center of Chinese Herbal Resources Science and Engineering, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China.
Guo Y; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.
Bao M; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.
Hong K; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.
Zhang Y; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.
Hu W; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.
Lei J; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China. leijp@mail.sysu.edu.cn.
Liu Y; Research Center of Chinese Herbal Resources Science and Engineering, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China. liuyq@gzucm.edu.cn.
Xu X; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China. xuxinfang@mail.sysu.edu.cn.

Mol Divers ; 27(2): 845-855, 2023 Apr.

Article em En | MEDLINE | ID: mdl-35751771

Assuntos

Antineoplásicos; Neoplasias do Colo; Humanos; Estrutura Molecular; Relação Estrutura-Atividade; Simulação de Acoplamento Molecular; Proteínas Proto-Oncogênicas c-akt; Antineoplásicos/química; Proliferação de Células; Linhagem Celular Tumoral; Neoplasias do Colo/tratamento farmacológico; Ensaios de Seleção de Medicamentos Antitumorais; Relação Dose-Resposta a Droga; Desenho de Fármacos

Palavras-chave

Akt1 inhibitor; Cytotoxicity; HCT-116; Hybrid molecule; Molecular docking

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias do Colo / Antineoplásicos Idioma: En Ano de publicação: 2023 Tipo de documento: Article País de afiliação: China

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