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Advancement in CRISPR/Cas9 Technology to Better Understand and Treat Neurological Disorders.
Datta, Aishika; Sarmah, Deepaneeta; Kaur, Harpreet; Chaudhary, Antra; Vadak, Namrata; Borah, Anupom; Shah, Sudhir; Wang, Xin; Bhattacharya, Pallab.
Afiliação
  • Datta A; Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad, Gandhinagar, Gujarat, 382355, India.
  • Sarmah D; Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad, Gandhinagar, Gujarat, 382355, India.
  • Kaur H; Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad, Gandhinagar, Gujarat, 382355, India.
  • Chaudhary A; Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad, Gandhinagar, Gujarat, 382355, India.
  • Vadak N; Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad, Gandhinagar, Gujarat, 382355, India.
  • Borah A; Cellular and Molecular Neurobiology Laboratory, Department of Life Science and Bioinformatics, Assam University, Silchar, Assam, 788011, India.
  • Shah S; Department of Neurology, SVPIMSR and NHL Municipal Medical College & Sterling Hospital, Ahmedabad, Gujarat, 380006, India.
  • Wang X; Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
  • Bhattacharya P; Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Ahmedabad, Gandhinagar, Gujarat, 382355, India. pallab.bhu@gmail.com.
Cell Mol Neurobiol ; 43(3): 1019-1035, 2023 Apr.
Article em En | MEDLINE | ID: mdl-35751791
ABSTRACT
Neurological disorders have complicated pathophysiology that may involve several genetic mutations. Conventional treatment has limitations as they only treat apparent symptoms. Although, personalized medicine is emerging as a promising neuro-intervention, lack of precision is the major pitfall. Clustered regularly interspaced short palindromic repeat (CRISPR)/Cas9 system is evolving as a technological platform that may overcome the therapeutic limitations towards precision medicine. In the future, targeting genes in neurological disorders may be the mainstay of modern therapy. The present review on CRISPR/Cas9 and its application in various neurological disorders may provide a platform for its future clinical relevance towards developing precise and personalized medicine.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Edição de Genes / Doenças do Sistema Nervoso Idioma: En Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Índia
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Edição de Genes / Doenças do Sistema Nervoso Idioma: En Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Índia