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Epidemiology, Clinico-Pathological Characteristics, and Comorbidities of SARS-CoV-2-Infected Pakistani Patients.
Omer, Saadia; Gondal, Mehrunnisa Fatima; Usman, Muhammad; Sarwar, Muhammad Bilal; Roman, Muhammad; Khan, Alam; Afzal, Nadeem; Qaiser, Tanveer Ahmed; Yasir, Muhammad; Shahzad, Faheem; Tahir, Romeeza; Ayub, Saima; Akram, Javed; Faizan, Raja Muhammad; Naveed, Muhammad Asif; Jahan, Shah.
Afiliação
  • Omer S; Department of Immunology, University of Health Sciences, Lahore, Pakistan.
  • Gondal MF; Institute of Public Health, Health Department, Government of Punjab, Lahore, Pakistan.
  • Usman M; Department of Community Medicine, Fatima Jinnah Medical University, Lahore, Pakistan.
  • Sarwar MB; Department of Immunology, University of Health Sciences, Lahore, Pakistan.
  • Roman M; Allama Iqbal Medical College, Jinnah Hospital, Lahore, Pakistan.
  • Khan A; Department of Immunology, University of Health Sciences, Lahore, Pakistan.
  • Afzal N; Department of Immunology, University of Health Sciences, Lahore, Pakistan.
  • Qaiser TA; Department of Immunology, University of Health Sciences, Lahore, Pakistan.
  • Yasir M; Department of Immunology, University of Health Sciences, Lahore, Pakistan.
  • Shahzad F; Department of Molecular Biology, Shaheed Zulfiqar Ali Bhutto Medical University, Islamabad, Pakistan.
  • Tahir R; Quadram Institute Bioscience, Norwich Research Park, Norwich, United Kingdom.
  • Ayub S; Department of Immunology, University of Health Sciences, Lahore, Pakistan.
  • Akram J; Department of Immunology, University of Health Sciences, Lahore, Pakistan.
  • Faizan RM; Institute of Public Health, Health Department, Government of Punjab, Lahore, Pakistan.
  • Naveed MA; Department of Immunology, University of Health Sciences, Lahore, Pakistan.
  • Jahan S; Department of Medicine, Shifa College of Medicine, Islamabad, Pakistan.
Front Cell Infect Microbiol ; 12: 800511, 2022.
Article em En | MEDLINE | ID: mdl-35755851
ABSTRACT
SARS-CoV-2 is a causative agent for COVID-19 disease, initially reported from Wuhan, China. The infected patients experienced mild to severe symptoms, resulting in several fatalities due to a weak understanding of its pathogenesis, which is the same even to date. This cross-sectional study has been designed on 452 symptomatic mild-to-moderate and severe/critical patients to understand the epidemiology and clinical characteristics of COVID-19 patients with their comorbidities and response to treatment. The mean age of the studied patients was 58 ± 14.42 years, and the overall male to female ratio was 61.7 to 38.2%, respectively. In total, 27.3% of the patients had a history of exposure, and 11.9% had a travel history, while for 60% of patients, the source of infection was unknown. The most prevalent signs and symptoms in ICU patients were dry cough, myalgia, shortness of breath, gastrointestinal discomfort, and abnormal chest X-ray (p < 0.001), along with a high percentage of hypertension (p = 0.007) and chronic obstructive pulmonary disease (p = 0.029) as leading comorbidities. The complete blood count indicators were significantly disturbed in severe patients, while the coagulation profile and D-dimer values were significantly higher in mild-to-moderate (non-ICU) patients (p < 0.001). The serum creatinine (1.22 µmol L-1; p = 0.016) and lactate dehydrogenase (619 µmol L-1; p < 0.001) indicators were significantly high in non-ICU patients, while raised values of total bilirubin (0.91 µmol L-1; p = 0.054), C-reactive protein (84.68 mg L-1; p = 0.001), and ferritin (996.81 mg L-1; p < 0.001) were found in ICU patients. The drug dexamethasone was the leading prescribed and administrated medicine to COVID-19 patients, followed by remdesivir, meropenem, heparin, and tocilizumab, respectively. A characteristic pattern of ground glass opacities, consolidation, and interlobular septal thickening was prominent in severely infected patients. These findings could be used for future research, control, and prevention of SARS-CoV-2-infected patients.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: SARS-CoV-2 / COVID-19 País/Região como assunto: Asia Idioma: En Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Paquistão

Texto completo: 1 Base de dados: MEDLINE Assunto principal: SARS-CoV-2 / COVID-19 País/Região como assunto: Asia Idioma: En Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Paquistão