Constitutive expression of cytochrome P450 1B1 endows testicular Leydig cells with susceptibility to 7,12-dimethylbenzanthracene-induced cell death.

Kim, Yoon-Jae; Park, Ji-Eun; Chung, Jin-Yong; Kim, Ji Young; Lee, Seung Gee; Lee, Seung-Jin; Yu, Wook-Joon; Kim, Hye Young; Kim, Hyeon Jun; Koh, Hyungjong; Bae, Hae-Rahn; Yoo, Young Hyun; Kim, Jong-Min

Kim, Yoon-Jae; Park, Ji-Eun; Chung, Jin-Yong; Kim, Ji Young; Lee, Seung Gee; Lee, Seung-Jin; Yu, Wook-Joon; Kim, Hye Young; Kim, Hyeon Jun; Koh, Hyungjong; Bae, Hae-Rahn; Yoo, Young Hyun; Kim, Jong-Min.

Afiliação

Kim YJ; Department of Anatomy and Cell Biology, College of Medicine, Dong-A University, Korea.
Park JE; Department of Anatomy and Cell Biology, College of Medicine, Dong-A University, Korea.
Chung JY; Department of Anatomy and Cell Biology, College of Medicine, Dong-A University, Korea.
Kim JY; Department of Anatomy and Cell Biology, College of Medicine, Dong-A University, Korea.
Lee SG; Department of Anatomy and Cell Biology, College of Medicine, Dong-A University, Korea.
Lee SJ; Developmental and Reproductive Toxicology Research Group, Korea Institute of Toxicology, Korea.
Yu WJ; Developmental and Reproductive Toxicology Research Group, Korea Institute of Toxicology, Korea.
Kim HY; Department of Anatomy and Cell Biology, College of Medicine, Dong-A University, Korea.
Kim HJ; Department of Orthopaedic Surgery, College of Medicine, Dong-A University, Korea.
Koh H; Department of Pharmacology, College of Medicine, Dong-A University, Korea.
Bae HR; Departmens of Physiology, College of Medicine, Dong-A University, Korea.
Yoo YH; Department of Anatomy and Cell Biology, College of Medicine, Dong-A University, Korea.
Kim JM; Department of Anatomy and Cell Biology, College of Medicine, Dong-A University, Korea.

J Toxicol Sci ; 47(8): 317-326, 2022.

Article em En | MEDLINE | ID: mdl-35908932

Assuntos

9,10-Dimetil-1,2-benzantraceno; Células Intersticiais do Testículo; 9,10-Dimetil-1,2-benzantraceno/metabolismo; 9,10-Dimetil-1,2-benzantraceno/toxicidade; Apoptose/genética; Caspase 3/genética; Caspase 3/metabolismo; Citocromo P-450 CYP1B1/genética; Citocromo P-450 CYP1B1/metabolismo; Humanos; Células Intersticiais do Testículo/metabolismo; Masculino; Proteína Supressora de Tumor p53/genética

Palavras-chave

7,12-dimethylbenzanthracene; Apoptosis; Cytochrome P450 1B1; Cytotoxicity; Leydig cells; Reactive oxygen species

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: 9,10-Dimetil-1,2-benzantraceno / Células Intersticiais do Testículo Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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