Novel isatin-based hybrids as potential anti-rheumatoid arthritis drug candidates: Synthesis and biological evaluation.

Chen, Jian; Lin, Xian; He, Juan; Liu, Jingfeng; He, Jiaxin; Tao, Cheng; Wang, Qingwen

Chen, Jian; Lin, Xian; He, Juan; Liu, Jingfeng; He, Jiaxin; Tao, Cheng; Wang, Qingwen.

Afiliação

Chen J; Department of Rheumatism and Immunology, Peking University Shenzhen Hospital, Shenzhen 518036, China; Shenzhen Key Laboratory of Inflammatory and Immunology Diseases, Shenzhen 518036, China. Electronic address: chenjian@jnu.edu.cn.
Lin X; Department of Rheumatism and Immunology, Peking University Shenzhen Hospital, Shenzhen 518036, China; Shenzhen Key Laboratory of Inflammatory and Immunology Diseases, Shenzhen 518036, China.
He J; Department of Rheumatism and Immunology, Peking University Shenzhen Hospital, Shenzhen 518036, China; Shenzhen Key Laboratory of Inflammatory and Immunology Diseases, Shenzhen 518036, China.
Liu J; Department of Rheumatism and Immunology, Peking University Shenzhen Hospital, Shenzhen 518036, China; Shenzhen Key Laboratory of Inflammatory and Immunology Diseases, Shenzhen 518036, China.
He J; Department of Rheumatism and Immunology, Peking University Shenzhen Hospital, Shenzhen 518036, China; Shenzhen Key Laboratory of Inflammatory and Immunology Diseases, Shenzhen 518036, China.
Tao C; Guangdong Provincial Key Laboratory of Research and Development of Natural Drugs, and School of Pharmacy, Guangdong Medical University, Dongguan 523808, China. Electronic address: taocheng@gdmu.edu.cn.
Wang Q; Department of Rheumatism and Immunology, Peking University Shenzhen Hospital, Shenzhen 518036, China; Shenzhen Key Laboratory of Inflammatory and Immunology Diseases, Shenzhen 518036, China. Electronic address: wqw_sw@163.com.

Bioorg Chem ; 128: 106063, 2022 11.

Article em En | MEDLINE | ID: mdl-35930922

Assuntos

Artrite Experimental; Artrite Reumatoide; Isatina; Animais; Apoptose; Artrite Experimental/metabolismo; Artrite Reumatoide/tratamento farmacológico; Artrite Reumatoide/metabolismo; Proliferação de Células; Células Cultivadas; Fibroblastos; Isatina/metabolismo; Isatina/farmacologia; Isatina/uso terapêutico; Camundongos; Proteínas Proto-Oncogênicas c-bcl-2/metabolismo; Vimentina/metabolismo

Palavras-chave

Apoptosis; CT5-2; Cell cycle arrest; Fibroblast-like synoviocytes; Isatin-honokiol hybrid; Rheumatoidarthritis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Artrite Experimental / Artrite Reumatoide / Isatina Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Artrite Experimental / Artrite Reumatoide / Isatina Idioma: En Ano de publicação: 2022 Tipo de documento: Article