Molecular Dynamics Modeling Based Investigation of the Effect of Freezing Rate on Lysozyme Stability.

Duran, Tibo; Minatovicz, Bruna; Bellucci, Ryan; Bai, Jun; Chaudhuri, Bodhisattwa

Duran, Tibo; Minatovicz, Bruna; Bellucci, Ryan; Bai, Jun; Chaudhuri, Bodhisattwa.

Afiliação

Duran T; Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, CT, 06269, USA.
Minatovicz B; Drug Product Development, BioTherapeutics Development, Janssen Research and Development, Malvern, PA, 19355, USA.
Bellucci R; Department of Chemical & Biomolecular Engineering, University of Connecticut, Storrs, CT, 06269, USA.
Bai J; Department of Computer Sciences and Engineering, University of Connecticut, Storrs, CT, 06269, USA.
Chaudhuri B; Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, CT, 06269, USA. bodhi.chaudhuri@uconn.edu.

Pharm Res ; 39(10): 2585-2596, 2022 Oct.

Article em En | MEDLINE | ID: mdl-35948746

Assuntos

Gelo; Simulação de Dinâmica Molecular; Congelamento; Muramidase; Proteínas/química; Água/química

Palavras-chave

freezing rate; ice-water interface; molecular dynamics simulations; protein stability

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Simulação de Dinâmica Molecular / Gelo Idioma: En Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos

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