Design, Synthesis and Biological Evaluation of Novel <i>N-Alkyl-4-Methyl-2,2- Dioxo-1H-2&#955;<sup>6</sup>,1-Benzothiazine-3-Carboxamides as</i> Promising Analgesics.

Ukrainets, Igor; Burian, Anna; Voloshchuk, Natali; Taran, Illia; Shishkina, Svitlana; Severina, Hanna; Grinevich, Lina; Sim, Galina; Burian, Kateryna; Georgiyants, Victoriya

Design, Synthesis and Biological Evaluation of Novel N-Alkyl-4-Methyl-2,2- Dioxo-1H-2λ⁶,1-Benzothiazine-3-Carboxamides as Promising Analgesics.

Ukrainets, Igor; Burian, Anna; Voloshchuk, Natali; Taran, Illia; Shishkina, Svitlana; Severina, Hanna; Grinevich, Lina; Sim, Galina; Burian, Kateryna; Georgiyants, Victoriya.

Afiliação

Ukrainets I; Department of Pharmaceutical Chemistry, National University of Pharmacy, 53 Pushkinska st., 61002 Kharkiv, Ukraine.
Burian A; Department of Pharmaceutical Chemistry, National University of Pharmacy, 53 Pushkinska st., 61002 Kharkiv, Ukraine.
Voloshchuk N; Department of Pharmacology, N.I. Pirogov Vinnitsa National Medical University, 56 Pirogov st., 21018 Vinnitsa, Ukraine.
Taran I; Department of Pharmacology, N.I. Pirogov Vinnitsa National Medical University, 56 Pirogov st., 21018 Vinnitsa, Ukraine.
Shishkina S; SSI "Institute for Single Crystals", National Academy of Sciences of Ukraine, 60 Nauki ave., 61001 Kharkiv, Ukraine.
Severina H; Department of Inorganic Chemistry, V.N. Karazin Kharkiv National University, 4 Svobody sq., 61077 Kharkiv, Ukraine.
Grinevich L; Department of Pharmaceutical Chemistry, National University of Pharmacy, 53 Pushkinska st., 61002 Kharkiv, Ukraine.
Sim G; Department of Medicinal Chemistry, National University of Pharmacy, 4 Valentynivska st., 61168 Kharkiv, Ukraine.
Burian K; Department of Pharmaceutical Chemistry, Far Eastern State Medical University, 35 Murav'eva- Amurskogo st., 680000, Khabarovsk, Russia.
Georgiyants V; Department of General Pharmacy and Safety of Drugs, National University of Pharmacy, 53 Pushkinska st., 61002 Kharkiv, Ukraine.

Med Chem ; 19(2): 174-192, 2023.

Article em En | MEDLINE | ID: mdl-35993458

Assuntos

Analgésicos; Anti-Inflamatórios; Simulação de Acoplamento Molecular; Analgésicos/farmacologia; Analgésicos/química; Anti-Inflamatórios/farmacologia; Relação Estrutura-Atividade; Indicadores e Reagentes/farmacologia

Palavras-chave

Benzothiazine-3-carboxamide; alkyl amides; analgesic activity; anti-inflammatory action; crystal structure; cyclooxygenase-2

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Analgésicos / Anti-Inflamatórios Idioma: En Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Ucrânia

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