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A tetravalent TREM2 agonistic antibody reduced amyloid pathology in a mouse model of Alzheimer's disease.
Zhao, Peng; Xu, Yuanzhong; Jiang, LuLin; Fan, Xuejun; Li, Leike; Li, Xin; Arase, Hisashi; Zhao, Yingjun; Cao, Wei; Zheng, Hui; Xu, Huaxi; Tong, Qingchun; Zhang, Ningyan; An, Zhiqiang.
Afiliação
  • Zhao P; Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
  • Xu Y; Center for Metabolic and Degenerative Diseases, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
  • Jiang L; Neuroscience Initiative, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.
  • Fan X; Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
  • Li L; Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
  • Li X; Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
  • Arase H; Department of Immunochemistry, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 565-0081, Japan.
  • Zhao Y; State Key Laboratory of Cellular Stress Biology, Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, School of Medicine, Xiamen University, Xiamen 361102, Fujian, China.
  • Cao W; Department of Anesthesiology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
  • Zheng H; Huffington Center on Aging, Baylor College of Medicine, Houston, TX 77030, USA.
  • Xu H; Center for Brain Sciences, the First Affiliated Hospital of Xiamen University, Institute of Neuroscience, Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Xiamen University, Xiamen 361102, Fujian, China.
  • Tong Q; Institute for Brain Science and Disease, Chongqing Medical University, Chongqing 400016, China.
  • Zhang N; Center for Metabolic and Degenerative Diseases, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
  • An Z; Texas Therapeutics Institute, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Sci Transl Med ; 14(661): eabq0095, 2022 09 07.
Article em En | MEDLINE | ID: mdl-36070367
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Alzheimer / Amiloidose Idioma: En Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Alzheimer / Amiloidose Idioma: En Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos