Super-enhancer-controlled positive feedback loop BRD4/ER&#945;-RET-ER&#945; promotes ER&#945;-positive breast cancer.

Zheng, Zao-Zao; Xia, Lin; Hu, Guo-Sheng; Liu, Jun-Yi; Hu, Ya-Hong; Chen, Yu-Jie; Peng, Jia-Yin; Zhang, Wen-Juan; Liu, Wen

Super-enhancer-controlled positive feedback loop BRD4/ERα-RET-ERα promotes ERα-positive breast cancer.

Zheng, Zao-Zao; Xia, Lin; Hu, Guo-Sheng; Liu, Jun-Yi; Hu, Ya-Hong; Chen, Yu-Jie; Peng, Jia-Yin; Zhang, Wen-Juan; Liu, Wen.

Afiliação

Zheng ZZ; State Key Laboratory of Cellular Stress Biology, School of Pharmaceutical Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiang'an South Road, Xiamen, Fujian 361102, China.
Xia L; Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiang'an South Road, Xiamen, Fujian 361102, China.
Hu GS; State Key Laboratory of Cellular Stress Biology, School of Pharmaceutical Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiang'an South Road, Xiamen, Fujian 361102, China.
Liu JY; Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiang'an South Road, Xiamen, Fujian 361102, China.
Hu YH; State Key Laboratory of Cellular Stress Biology, School of Pharmaceutical Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiang'an South Road, Xiamen, Fujian 361102, China.
Chen YJ; Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiang'an South Road, Xiamen, Fujian 361102, China.
Peng JY; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Public Health, Faculty of Medicine and Life Sciences, Xiamen University, Xiang'an South Road, Xiamen, Fujian 361102, China.
Zhang WJ; State Key Laboratory of Cellular Stress Biology, School of Pharmaceutical Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiang'an South Road, Xiamen, Fujian 361102, China.
Liu W; Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiang'an South Road, Xiamen, Fujian 361102, China.

Nucleic Acids Res ; 50(18): 10230-10248, 2022 10 14.

Article em En | MEDLINE | ID: mdl-36124682

Assuntos

Neoplasias da Mama; Receptor alfa de Estrogênio; Neoplasias da Mama/tratamento farmacológico; Neoplasias da Mama/genética; Neoplasias da Mama/metabolismo; Neoplasias da Mama/patologia; Proteínas de Ciclo Celular; Linhagem Celular Tumoral; Proliferação de Células; Resistencia a Medicamentos Antineoplásicos; Receptor alfa de Estrogênio/genética; Receptor alfa de Estrogênio/metabolismo; Estrogênios; Retroalimentação Fisiológica; Feminino; Regulação Neoplásica da Expressão Gênica; Humanos; Proteínas Nucleares/genética; Proteínas Nucleares/metabolismo; Proteínas Tirosina Quinases/metabolismo; Proteínas Proto-Oncogênicas c-ret/genética; Proteínas Proto-Oncogênicas c-ret/metabolismo; Proteínas Proto-Oncogênicas c-ret/uso terapêutico; Tamoxifeno/farmacologia; Fatores de Transcrição/genética; Fatores de Transcrição/metabolismo

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Receptor alfa de Estrogênio Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Receptor alfa de Estrogênio Idioma: En Ano de publicação: 2022 Tipo de documento: Article