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Acipimox in Mitochondrial Myopathy (AIMM): study protocol for a randomised, double-blinded, placebo-controlled, adaptive design trial of the efficacy of acipimox in adult patients with mitochondrial myopathy.
Abouhajar, Alaa; Alcock, Lisa; Bigirumurame, Theophile; Bradley, Penny; Brown, Laura; Campbell, Ian; Del Din, Silvia; Faitg, Julie; Falkous, Gavin; Gorman, Gráinne S; Lakey, Rachel; McFarland, Robert; Newman, Jane; Rochester, Lynn; Ryan, Vicky; Smith, Hesther; Steel, Alison; Stefanetti, Renae J; Su, Huizhong; Taylor, Robert W; Thomas, Naomi J P; Tuppen, Helen; Vincent, Amy E; Warren, Charlotte; Watson, Gillian.
Afiliação
  • Abouhajar A; Newcastle Clinical Trials Unit, 1-4 Claremont Terrace, Newcastle University, Newcastle upon Tyne, NE2 4AE, UK.
  • Alcock L; Brain and Movement Research Group, Clinical Ageing Research Unit, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE4 5PL, UK.
  • Bigirumurame T; Population Health Sciences Institute, Newcastle University, Ridley 1 Building, Newcastle upon Tyne, NE1 7RU, UK.
  • Bradley P; Pharmacy Directorate, Newcastle Upon Tyne Hospitals NHS Foundation Trust, Freeman Hospital, Freeman Road, Newcastle Upon Tyne, NE7 7DN, UK.
  • Brown L; Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, NE2 4HH, UK.
  • Campbell I; Pharmacy Directorate, Newcastle Upon Tyne Hospitals NHS Foundation Trust, Freeman Hospital, Freeman Road, Newcastle Upon Tyne, NE7 7DN, UK.
  • Del Din S; Brain and Movement Research Group, Clinical Ageing Research Unit, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE4 5PL, UK.
  • Faitg J; Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, NE2 4HH, UK.
  • Falkous G; Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, NE2 4HH, UK.
  • Gorman GS; Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, NE2 4HH, UK.
  • Lakey R; NHS Highly Specialised Service for Rare Mitochondrial Disorders, Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne, NE1 4LP, UK.
  • McFarland R; Newcastle Clinical Trials Unit, 1-4 Claremont Terrace, Newcastle University, Newcastle upon Tyne, NE2 4AE, UK.
  • Newman J; Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, NE2 4HH, UK.
  • Rochester L; NHS Highly Specialised Service for Rare Mitochondrial Disorders, Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne, NE1 4LP, UK.
  • Ryan V; Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, NE2 4HH, UK.
  • Smith H; Brain and Movement Research Group, Clinical Ageing Research Unit, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, NE4 5PL, UK.
  • Steel A; Population Health Sciences Institute, Newcastle University, Ridley 1 Building, Newcastle upon Tyne, NE1 7RU, UK.
  • Stefanetti RJ; Pharmacy Directorate, Newcastle Upon Tyne Hospitals NHS Foundation Trust, Freeman Hospital, Freeman Road, Newcastle Upon Tyne, NE7 7DN, UK.
  • Su H; Newcastle Clinical Trials Unit, 1-4 Claremont Terrace, Newcastle University, Newcastle upon Tyne, NE2 4AE, UK.
  • Taylor RW; Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, NE2 4HH, UK.
  • Thomas NJP; Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, NE2 4HH, UK.
  • Tuppen H; Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, NE2 4HH, UK.
  • Vincent AE; NHS Highly Specialised Service for Rare Mitochondrial Disorders, Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne, NE1 4LP, UK.
  • Warren C; Wellcome Centre for Mitochondrial Research, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle Upon Tyne, NE2 4HH, UK. naomi.thomas@newcastle.ac.uk.
  • Watson G; NHS Highly Specialised Service for Rare Mitochondrial Disorders, Newcastle Upon Tyne Hospitals NHS Foundation Trust, Newcastle Upon Tyne, NE1 4LP, UK. naomi.thomas@newcastle.ac.uk.
Trials ; 23(1): 789, 2022 Sep 20.
Article em En | MEDLINE | ID: mdl-36127727
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Miopatias Mitocondriais / Doenças Musculares Idioma: En Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Miopatias Mitocondriais / Doenças Musculares Idioma: En Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Reino Unido