Hyperacmosin R, a New Decarbonyl Prenylphloroglucinol with Unusual Spiroketal Subunit from Hypericum acmosepalum.
Molecules
; 27(18)2022 Sep 13.
Article
em En
| MEDLINE
| ID: mdl-36144668
ABSTRACT
Two previously undescribed polycyclic polyprenylated acylphloroglucinols, hyperacmosins R-S (1-2), were obtained from the aerial parts of Hypericum acmosepalum. Their structures were elucidated by extensive spectroscopic analysis and electronic circular dichroism calculation (ECD). Compound 1 featured an unprecedented 5,8-spiroketal subunit as well as the loss of C-2' carbonyl in the phloroglucinol ring. In addition, compounds 1 and 4 showed weak hepatoprotective activity against paracetamol-induced HepG2 cell damage at 10 µm. The plausible biosynthetic pathway of 1 was proposed via a retro-Clasisen reaction and decarboxylation.
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Base de dados:
MEDLINE
Assunto principal:
Hypericum
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
China