Mast cell regranulation requires a metabolic switch involving mTORC1 and a glucose-6-phosphate transporter.

Iskarpatyoti, Jason A; Shi, Jianling; Abraham, Mathew A; Rathore, Abhay P S; Miao, Yuxuan; Abraham, Soman N

Iskarpatyoti, Jason A; Shi, Jianling; Abraham, Mathew A; Rathore, Abhay P S; Miao, Yuxuan; Abraham, Soman N.

Afiliação

Iskarpatyoti JA; Department of Molecular Genetics & Microbiology, Duke University Medical Center, Durham, NC 27710, USA.
Shi J; Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA.
Abraham MA; Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA.
Rathore APS; Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA.
Miao Y; Ben May Department of Cancer Research, The University of Chicago, Chicago, IL 60637, USA.
Abraham SN; Department of Molecular Genetics & Microbiology, Duke University Medical Center, Durham, NC 27710, USA; Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA; Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA; Program in Emerging Infectious

Cell Rep ; 40(13): 111346, 2022 09 27.

Article em En | MEDLINE | ID: mdl-36170813

Assuntos

Degranulação Celular; Mastócitos; Trifosfato de Adenosina/metabolismo; Animais; Antiporters; Glucose/metabolismo; Glucose-6-Fosfato/metabolismo; Lipídeos; Mastócitos/metabolismo; Alvo Mecanístico do Complexo 1 de Rapamicina/metabolismo; Camundongos; Proteínas de Transporte de Fosfato/metabolismo

Palavras-chave

CP: Metabolism; Slc37a2; mTOR; mast cell; metabolism; regranulation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Degranulação Celular / Mastócitos Idioma: En Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Estados Unidos

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