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Visible-Light-Mediated Energy Transfer Enables the Synthesis of ß-Lactams via Intramolecular Hydrogen Atom Transfer.
Oddy, Meghan J; Kusza, Daniel A; Epton, Ryan G; Lynam, Jason M; Unsworth, William P; Petersen, Wade F.
Afiliação
  • Oddy MJ; Department of Chemistry, University of Cape Town, Rondebosch, Cape Town, 7700, South Africa.
  • Kusza DA; Department of Chemistry, University of Cape Town, Rondebosch, Cape Town, 7700, South Africa.
  • Epton RG; Department of Chemistry, University of York, York, YO10 5DD, UK.
  • Lynam JM; Department of Chemistry, University of York, York, YO10 5DD, UK.
  • Unsworth WP; Department of Chemistry, University of York, York, YO10 5DD, UK.
  • Petersen WF; Department of Chemistry, University of Cape Town, Rondebosch, Cape Town, 7700, South Africa.
Angew Chem Int Ed Engl ; 61(48): e202213086, 2022 11 25.
Article em En | MEDLINE | ID: mdl-36205440
ABSTRACT
The synthesis of 2-azetidinones (ß-lactams) from simple acrylamide starting materials by visible-light-mediated energy transfer catalysis is reported. The reaction features a C(sp3 )-H functionalization via a variation of the Norrish-Yang photocyclization involving a carbon-to-carbon 1,5-hydrogen atom transfer (supported by deuterium labelling and DFT calculations) and can be used for the construction of a diverse range of ß-lactam products.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Beta-Lactamas / Hidrogênio Idioma: En Ano de publicação: 2022 Tipo de documento: Article País de afiliação: África do Sul
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Beta-Lactamas / Hidrogênio Idioma: En Ano de publicação: 2022 Tipo de documento: Article País de afiliação: África do Sul