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Steroid hormone catabolites activate the pyrin inflammasome through a non-canonical mechanism.
Magnotti, Flora; Chirita, Daria; Dalmon, Sarah; Martin, Amandine; Bronnec, Pauline; Sousa, Jeremy; Helynck, Olivier; Lee, Wonyong; Kastner, Daniel L; Chae, Jae Jin; McDermott, Michael F; Belot, Alexandre; Popoff, Michel; Sève, Pascal; Georgin-Lavialle, Sophie; Munier-Lehmann, Hélène; Tran, Tu Anh; De Langhe, Ellen; Wouters, Carine; Jamilloux, Yvan; Henry, Thomas.
Afiliação
  • Magnotti F; CIRI, Centre International de Recherche en Infectiologie, Inserm U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, University Lyon, 69007 Lyon, France.
  • Chirita D; CIRI, Centre International de Recherche en Infectiologie, Inserm U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, University Lyon, 69007 Lyon, France.
  • Dalmon S; CIRI, Centre International de Recherche en Infectiologie, Inserm U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, University Lyon, 69007 Lyon, France.
  • Martin A; CIRI, Centre International de Recherche en Infectiologie, Inserm U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, University Lyon, 69007 Lyon, France.
  • Bronnec P; CIRI, Centre International de Recherche en Infectiologie, Inserm U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, University Lyon, 69007 Lyon, France.
  • Sousa J; CIRI, Centre International de Recherche en Infectiologie, Inserm U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, University Lyon, 69007 Lyon, France.
  • Helynck O; Institut Pasteur, Université de Paris Cité, CNRS UMR3523, Chemistry and Biocatalysis Unit, 75724 Paris Cedex 15, France.
  • Lee W; Inflammatory Disease Section, Metabolic, Cardiovascular and Inflammatory Disease Genomics Branch, National Human Genome Research Institute, Bethesda, MD, USA.
  • Kastner DL; Inflammatory Disease Section, Metabolic, Cardiovascular and Inflammatory Disease Genomics Branch, National Human Genome Research Institute, Bethesda, MD, USA.
  • Chae JJ; Inflammatory Disease Section, Metabolic, Cardiovascular and Inflammatory Disease Genomics Branch, National Human Genome Research Institute, Bethesda, MD, USA.
  • McDermott MF; Leeds Institute of Rheumatic and Musculoskeletal Medicine, St James's University Hospital, Leeds, UK.
  • Belot A; CIRI, Centre International de Recherche en Infectiologie, Inserm U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, University Lyon, 69007 Lyon, France; Department of Pediatric Nephrology, Rheumatology, Dermatology, Reference Centre for Rheumatic, AutoImmune and Systemic Diseases i
  • Popoff M; Bacterial Toxins, Institut Pasteur, Paris, France.
  • Sève P; Department of Internal Medicine, University Hospital Croix-Rousse, Lyon 1 University, Lyon, France.
  • Georgin-Lavialle S; Sorbonne University, Department of Internal Medicine, Tenon Hospital, DMU 3ID, AP-HP, National Reference Center for Autoinflammatory Diseases and Inflammatory Amyloidosis (CEREMAIA), INSERM U938, Paris, France.
  • Munier-Lehmann H; Institut Pasteur, Université de Paris Cité, CNRS UMR3523, Chemistry and Biocatalysis Unit, 75724 Paris Cedex 15, France.
  • Tran TA; Department of Pediatrics, Carémeau Hospital, CHU Nîmes, Nîmes, France.
  • De Langhe E; Division of Rheumatology, University Hospitals Leuven, Leuven, Belgium; Laboratory of Tissue Homeostasis and Disease, Department of Development and Regeneration, KU Leuven, Leuven, Belgium.
  • Wouters C; KU Leuven-University of Leuven, Department of Microbiology and Immunology, Laboratory of Adaptive Immunology & Immunobiology, Leuven, Belgium; Department of Pediatrics, University Hospitals Leuven, 3000 Leuven, Belgium.
  • Jamilloux Y; CIRI, Centre International de Recherche en Infectiologie, Inserm U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, University Lyon, 69007 Lyon, France; LIFE, Lyon Immunopathology Federation, Lyon, France; Department of Internal Medicine, University Hospital Croix-Rousse, Lyon 1 Un
  • Henry T; CIRI, Centre International de Recherche en Infectiologie, Inserm U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, University Lyon, 69007 Lyon, France. Electronic address: thomas.henry@inserm.fr.
Cell Rep ; 41(2): 111472, 2022 10 11.
Article em En | MEDLINE | ID: mdl-36223753
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Febre Familiar do Mediterrâneo / Inflamassomos / Pirina Idioma: En Ano de publicação: 2022 Tipo de documento: Article País de afiliação: França
Texto completo
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XML
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Febre Familiar do Mediterrâneo / Inflamassomos / Pirina Idioma: En Ano de publicação: 2022 Tipo de documento: Article País de afiliação: França