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Discovery of 42 genome-wide significant loci associated with dyslexia.
Doust, Catherine; Fontanillas, Pierre; Eising, Else; Gordon, Scott D; Wang, Zhengjun; Alagöz, Gökberk; Molz, Barbara; Pourcain, Beate St; Francks, Clyde; Marioni, Riccardo E; Zhao, Jingjing; Paracchini, Silvia; Talcott, Joel B; Monaco, Anthony P; Stein, John F; Gruen, Jeffrey R; Olson, Richard K; Willcutt, Erik G; DeFries, John C; Pennington, Bruce F; Smith, Shelley D; Wright, Margaret J; Martin, Nicholas G; Auton, Adam; Bates, Timothy C; Fisher, Simon E; Luciano, Michelle.
Afiliação
  • Doust C; Department of Psychology, University of Edinburgh, Edinburgh, UK.
  • Fontanillas P; 23andMe, Inc., Sunnyvale, CA, USA.
  • Eising E; Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, the Netherlands.
  • Gordon SD; Genetic Epidemiology Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
  • Wang Z; School of Psychology, Shaanxi Normal University and Shaanxi Key Research Center of Child Mental and Behavioral Health, Xi'an, China.
  • Alagöz G; Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, the Netherlands.
  • Molz B; Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, the Netherlands.
  • Pourcain BS; Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, the Netherlands.
  • Francks C; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands.
  • Marioni RE; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
  • Zhao J; Language and Genetics Department, Max Planck Institute for Psycholinguistics, Nijmegen, the Netherlands.
  • Paracchini S; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands.
  • Talcott JB; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
  • Monaco AP; School of Psychology, Shaanxi Normal University and Shaanxi Key Research Center of Child Mental and Behavioral Health, Xi'an, China.
  • Stein JF; School of Medicine, University of St Andrews, St Andrews, UK.
  • Gruen JR; Institute of Health and Neurodevelopment, Aston University, Birmingham, UK.
  • Olson RK; Office of the President, Tufts University, Medford, MA, USA.
  • Willcutt EG; Department of Physiology, Anatomy and Genetics, Oxford University, Oxford, UK.
  • DeFries JC; Departments of Pediatrics and Genetics, Yale Medical School, New Haven, CT, USA.
  • Pennington BF; Department of Psychology and Neuroscience, University of Colorado, Boulder, CO, USA.
  • Smith SD; Institute for Behavioral Genetics, University of Colorado, Boulder, CO, USA.
  • Wright MJ; Department of Psychology and Neuroscience, University of Colorado, Boulder, CO, USA.
  • Martin NG; Institute for Behavioral Genetics, University of Colorado, Boulder, CO, USA.
  • Auton A; Department of Psychology and Neuroscience, University of Colorado, Boulder, CO, USA.
  • Bates TC; Institute for Behavioral Genetics, University of Colorado, Boulder, CO, USA.
  • Fisher SE; Department of Psychology, University of Denver, Denver, CO, USA.
  • Luciano M; Department of Neurological Sciences, College of Medicine, University of Nebraska Medical Center, Omaha, NE, USA.
Nat Genet ; 54(11): 1621-1629, 2022 11.
Article em En | MEDLINE | ID: mdl-36266505
ABSTRACT
Reading and writing are crucial life skills but roughly one in ten children are affected by dyslexia, which can persist into adulthood. Family studies of dyslexia suggest heritability up to 70%, yet few convincing genetic markers have been found. Here we performed a genome-wide association study of 51,800 adults self-reporting a dyslexia diagnosis and 1,087,070 controls and identified 42 independent genome-wide significant loci 15 in genes linked to cognitive ability/educational attainment, and 27 new and potentially more specific to dyslexia. We validated 23 loci (13 new) in independent cohorts of Chinese and European ancestry. Genetic etiology of dyslexia was similar between sexes, and genetic covariance with many traits was found, including ambidexterity, but not neuroanatomical measures of language-related circuitry. Dyslexia polygenic scores explained up to 6% of variance in reading traits, and might in future contribute to earlier identification and remediation of dyslexia.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dislexia / Estudo de Associação Genômica Ampla Idioma: En Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
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XML
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dislexia / Estudo de Associação Genômica Ampla Idioma: En Ano de publicação: 2022 Tipo de documento: Article País de afiliação: Reino Unido