Access to 6-Deoxy-heptose Constructs by One Carbon Homologation of Hexoses with Malononitrile: Divergent Synthesis of Campylobacter jejuni Strain 81-176 Capsular Trisaccharide Repeating Unit Derivatives.
Org Lett
; 24(43): 7944-7949, 2022 11 04.
Article
em En
| MEDLINE
| ID: mdl-36287193
ABSTRACT
An efficient approach to 6-deoxy-heptose constructs has been established by one-carbon homologation of the sugar chain of hexoses. The reaction features the formation of sugar-based α-substituted propanedinitriles and ensuing diverse oxidative transformations under mild reaction conditions that are compatible with a wide range of sugars bearing various functional/protecting groups. The applications of this method are demonstrated by a divergent assembly of Campylobacter jejuni strain 81-176 capsular trisaccharide repeating unit derivatives.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Campylobacter jejuni
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
China