The role of complement in glomerulonephritis-are novel therapies ready for prime time?
Nephrol Dial Transplant
; 38(8): 1789-1797, 2023 07 31.
Article
em En
| MEDLINE
| ID: mdl-36307926
ABSTRACT
The complement system plays a key pathogenic role in glomerular diseases with a diverse range of aetiologies, including C3 glomerulopathy, immunoglobulin A nephropathy, membranous nephropathy, ANCA-associated vasculitis and lupus nephritis. Several novel therapies targeting complement activity have recently been developed, which have now been approved or are in the late stages of clinical development. In this review, potential benefits and challenges of targeting the complement system in glomerular disease are discussed. We summarize current understanding of the role of complement, and the novel targeted therapies that are being developed for the treatment of glomerular disease.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Nefrite Lúpica
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Glomerulonefrite Membranosa
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Glomerulonefrite
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Glomerulonefrite por IGA
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Reino Unido