Synthesis, biological evaluation and computational studies of pyrazole derivatives as <i>Mycobacterium tuberculosis</i> CYP121A1 inhibitors.

Synthesis, biological evaluation and computational studies of pyrazole derivatives as Mycobacterium tuberculosis CYP121A1 inhibitors.

Alshabani, Lama A; Kumar, Amit; Willcocks, Sam J; Srithiran, Gayathri; Bhakta, Sanjib; Estrada, D Fernando; Simons, Claire.

Afiliação

Alshabani LA; School of Pharmacy & Pharmaceutical Sciences, Cardiff University King Edward VII Avenue Cardiff CF10 3NB UK simonsc@cardiff.ac.uk.
Kumar A; Department of Biochemistry, Jacobs School of Medicine and Biomedical Science, University at Buffalo Buffalo New York-14203 USA.
Willcocks SJ; Department of Infection Biology, The London School of Hygiene and Tropical Medicine London WC1E 7HT UK.
Srithiran G; Mycobacteria Research Laboratory, Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck, University of London London WC1E 7HX UK.
Bhakta S; Mycobacteria Research Laboratory, Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck, University of London London WC1E 7HX UK.
Estrada DF; Mycobacteria Research Laboratory, Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck, University of London London WC1E 7HX UK.
Simons C; Department of Biochemistry, Jacobs School of Medicine and Biomedical Science, University at Buffalo Buffalo New York-14203 USA.

RSC Med Chem ; 13(11): 1350-1360, 2022 Nov 16.

Article em En | MEDLINE | ID: mdl-36426236

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article