Post-translational modification of lysine residues in erythrocyte &#945;-synuclein.

Amagai, Ryosuke; Yoshioka, Sakura; Otomo, Riki; Nagano, Hidekazu; Hashimoto, Naoko; Sakakibara, Ryuji; Tanaka, Tomoaki; Okado-Matsumoto, Ayako

Post-translational modification of lysine residues in erythrocyte α-synuclein.

Amagai, Ryosuke; Yoshioka, Sakura; Otomo, Riki; Nagano, Hidekazu; Hashimoto, Naoko; Sakakibara, Ryuji; Tanaka, Tomoaki; Okado-Matsumoto, Ayako.

Afiliação

Amagai R; Laboratory of Biochemistry, Department of Biology, Faculty of Science, Toho University, 2-2-1 Miyama, Funabashi, Chiba 274-8510, Japan.
Yoshioka S; Laboratory of Biochemistry, Department of Biology, Faculty of Science, Toho University, 2-2-1 Miyama, Funabashi, Chiba 274-8510, Japan.
Otomo R; Laboratory of Biochemistry, Department of Biology, Faculty of Science, Toho University, 2-2-1 Miyama, Funabashi, Chiba 274-8510, Japan.
Nagano H; Department of Molecular Diagnosis, Chiba University Graduate School of Medicine, Chiba, Chiba 260-8670, Japan.
Hashimoto N; Department of Molecular Diagnosis, Chiba University Graduate School of Medicine, Chiba, Chiba 260-8670, Japan.
Sakakibara R; Division of Neurology, Department of Internal Medicine, Sakura Medical Center, Toho University, Sakura, Chiba 285-8741, Japan.
Tanaka T; Department of Molecular Diagnosis, Chiba University Graduate School of Medicine, Chiba, Chiba 260-8670, Japan.
Okado-Matsumoto A; Laboratory of Biochemistry, Department of Biology, Faculty of Science, Toho University, 2-2-1 Miyama, Funabashi, Chiba 274-8510, Japan.

J Biochem ; 173(3): 177-184, 2023 Mar 07.

Article em En | MEDLINE | ID: mdl-36469357

Assuntos

Lisina; alfa-Sinucleína; Eritrócitos; Fosforilação; Processamento de Proteína Pós-Traducional; Humanos

Palavras-chave

Parkinson's disease; erythrocyte; post-translational modification; synucleinopathy; α-synuclein.Abbreviations: aa, amino acids; AGE, advanced glycation end product; BBB, bloodbrain barrier; CML, NÎµ-(1-carboxymethyl)-L-lysine; CNS, central nervous system; EVs, extracellular vesicles; IP, immunoprecipitation; LCMS/MS, liquid chromatographymass spectrometry; PBS, phosphate buffered saline; PD, Parkinson's disease; PTM, post-translational modification; SUMO, small ubiquitin-related modifier

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Alfa-Sinucleína / Lisina Idioma: En Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Japão

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