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FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2.
Brevini, Teresa; Maes, Mailis; Webb, Gwilym J; John, Binu V; Fuchs, Claudia D; Buescher, Gustav; Wang, Lu; Griffiths, Chelsea; Brown, Marnie L; Scott, William E; Pereyra-Gerber, Pehuén; Gelson, William T H; Brown, Stephanie; Dillon, Scott; Muraro, Daniele; Sharp, Jo; Neary, Megan; Box, Helen; Tatham, Lee; Stewart, James; Curley, Paul; Pertinez, Henry; Forrest, Sally; Mlcochova, Petra; Varankar, Sagar S; Darvish-Damavandi, Mahnaz; Mulcahy, Victoria L; Kuc, Rhoda E; Williams, Thomas L; Heslop, James A; Rossetti, Davide; Tysoe, Olivia C; Galanakis, Vasileios; Vila-Gonzalez, Marta; Crozier, Thomas W M; Bargehr, Johannes; Sinha, Sanjay; Upponi, Sara S; Fear, Corrina; Swift, Lisa; Saeb-Parsy, Kourosh; Davies, Susan E; Wester, Axel; Hagström, Hannes; Melum, Espen; Clements, Darran; Humphreys, Peter; Herriott, Jo; Kijak, Edyta; Cox, Helen.
Afiliação
  • Brevini T; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK. tb647@cam.ac.uk.
  • Maes M; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Department of Medicine, University of Cambridge, Cambridge, UK.
  • Webb GJ; Cambridge Liver Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
  • John BV; Division of Gastroenterology and Hepatology, University of Miami and Miami VA Health System, Miami, FL, USA.
  • Fuchs CD; Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.
  • Buescher G; Department of Medicine, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany.
  • Wang L; Transplant and Regenerative Medicine Laboratory, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
  • Griffiths C; Transplant and Regenerative Medicine Laboratory, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
  • Brown ML; Transplant and Regenerative Medicine Laboratory, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
  • Scott WE; Transplant and Regenerative Medicine Laboratory, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
  • Pereyra-Gerber P; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Department of Medicine, University of Cambridge, Cambridge, UK.
  • Gelson WTH; Cambridge Liver Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
  • Brown S; Department of Medicine, University of Cambridge, Cambridge, UK.
  • Dillon S; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK.
  • Muraro D; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK.
  • Sharp J; Wellcome Sanger Institute, Hinxton, UK.
  • Neary M; Centre of Excellence in Long-acting Therapeutics (CELT), Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.
  • Box H; Centre of Excellence in Long-acting Therapeutics (CELT), Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.
  • Tatham L; Centre of Excellence in Long-acting Therapeutics (CELT), Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.
  • Stewart J; Centre of Excellence in Long-acting Therapeutics (CELT), Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.
  • Curley P; Department of Infection Biology and Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK.
  • Pertinez H; Centre of Excellence in Long-acting Therapeutics (CELT), Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.
  • Forrest S; Centre of Excellence in Long-acting Therapeutics (CELT), Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.
  • Mlcochova P; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Department of Medicine, University of Cambridge, Cambridge, UK.
  • Varankar SS; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Department of Medicine, University of Cambridge, Cambridge, UK.
  • Darvish-Damavandi M; Division of Gastroenterology and Hepatology, University of Miami and Miami VA Health System, Miami, FL, USA.
  • Mulcahy VL; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK.
  • Kuc RE; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK.
  • Williams TL; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.
  • Heslop JA; Academic Department of Medical Genetics, University of Cambridge, Cambridge, UK.
  • Rossetti D; Experimental Medicine and Immunotherapeutics, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.
  • Tysoe OC; Experimental Medicine and Immunotherapeutics, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK.
  • Galanakis V; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK.
  • Vila-Gonzalez M; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK.
  • Crozier TWM; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK.
  • Bargehr J; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, UK.
  • Sinha S; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK.
  • Upponi SS; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK.
  • Fear C; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Department of Medicine, University of Cambridge, Cambridge, UK.
  • Swift L; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK.
  • Saeb-Parsy K; Department of Medicine, University of Cambridge, Cambridge, UK.
  • Davies SE; Division of Cardiovascular Medicine, University of Cambridge, Cambridge, UK.
  • Wester A; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK.
  • Hagström H; Division of Cardiovascular Medicine, University of Cambridge, Cambridge, UK.
  • Melum E; Department of Radiology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
  • Clements D; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, UK.
  • Humphreys P; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, UK.
  • Herriott J; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, UK.
  • Kijak E; Roy Calne Transplant Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
  • Cox H; Department of Histopathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Nature ; 615(7950): 134-142, 2023 03.
Article em En | MEDLINE | ID: mdl-36470304
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores Virais / Ácido Ursodesoxicólico / Enzima de Conversão de Angiotensina 2 / COVID-19 Idioma: En Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores Virais / Ácido Ursodesoxicólico / Enzima de Conversão de Angiotensina 2 / COVID-19 Idioma: En Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Reino Unido