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Recent advances in the use of legume lectins for the diagnosis and treatment of breast cancer.
Cavada, Benildo Sousa; Oliveira, Messias Vital de; Osterne, Vinícius Jose Silva; Pinto-Junior, Vanir Reis; Martins, Francisco William Viana; Correia-Neto, Cornevile; Pinheiro, Ronald Feitosa; Leal, Rodrigo Bainy; Nascimento, Kyria Santiago.
Afiliação
  • Cavada BS; BioMol Lab, Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Ceará, Fortaleza, Brazil. Electronic address: bscavada@ufc.br.
  • Oliveira MV; BioMol Lab, Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Ceará, Fortaleza, Brazil.
  • Osterne VJS; BioMol Lab, Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Ceará, Fortaleza, Brazil; Laboratory of Biochemistry and Glycobiology, Department of Biotechnology, Ghent University, Ghent, Belgium.
  • Pinto-Junior VR; BioMol Lab, Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Ceará, Fortaleza, Brazil; Departamento de Física, Universidade Federal do Ceará, Fortaleza, Brazil.
  • Martins FWV; BioMol Lab, Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Ceará, Fortaleza, Brazil.
  • Correia-Neto C; BioMol Lab, Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Ceará, Fortaleza, Brazil.
  • Pinheiro RF; Núcleo de Pesquisa e Desenvolvimento de Medicações (NPDM), Universidade Federal do Ceará, Fortaleza, Brazil.
  • Leal RB; Departamento de Bioquímica, Universidade Federal de Santa Catarina, Florianópolis, Santa Catarina, Brazil.
  • Nascimento KS; BioMol Lab, Departamento de Bioquímica e Biologia Molecular, Universidade Federal do Ceará, Fortaleza, Brazil. Electronic address: kyriasantiago@ufc.br.
Biochimie ; 208: 100-116, 2023 May.
Article em En | MEDLINE | ID: mdl-36586566
Poor lifestyle choices and genetic predisposition are factors that increase the number of cancer cases, one example being breast cancer, the third most diagnosed type of malignancy. Currently, there is a demand for the development of new strategies to ensure early detection and treatment options that could contribute to the complete remission of breast tumors, which could lead to increased overall survival rates. In this context, the glycans observed at the surface of cancer cells are presented as efficient tumor cell markers. These carbohydrate structures can be recognized by lectins which can act as decoders of the glycocode. The application of plant lectins as tools for diagnosis/treatment of breast cancer encompasses the detection and sorting of glycans found in healthy and malignant cells. Here, we present an overview of the most recent studies in this field, demonstrating the potential of lectins as: mapping agents to detect differentially expressed glycans in breast cancer, as histochemistry/cytochemistry analysis agents, in lectin arrays, immobilized in chromatographic matrices, in drug delivery, and as biosensing agents. In addition, we describe lectins that present antiproliferative effects by themselves and/or in conjunction with other drugs in a synergistic effect.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Fabaceae Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Fabaceae Idioma: En Ano de publicação: 2023 Tipo de documento: Article