Cancer cells resistant to immune checkpoint blockade acquire interferon-associated epigenetic memory to sustain T cell dysfunction.

Qiu, Jingya; Xu, Bihui; Ye, Darwin; Ren, Diqiu; Wang, Shangshang; Benci, Joseph L; Xu, Yuanming; Ishwaran, Hemant; Beltra, Jean-Christophe; Wherry, E John; Shi, Junwei; Minn, Andy J

Qiu, Jingya; Xu, Bihui; Ye, Darwin; Ren, Diqiu; Wang, Shangshang; Benci, Joseph L; Xu, Yuanming; Ishwaran, Hemant; Beltra, Jean-Christophe; Wherry, E John; Shi, Junwei; Minn, Andy J.

Afiliação

Qiu J; Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, USA.
Xu B; Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA, USA.
Ye D; Mark Foundation Center for Immunotherapy, Immune Signaling, and Radiation, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Ren D; Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, USA.
Wang S; Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA, USA.
Benci JL; Incyte, Wilmington, DE, USA.
Xu Y; Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, USA.
Ishwaran H; Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA, USA.
Beltra JC; Mark Foundation Center for Immunotherapy, Immune Signaling, and Radiation, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Wherry EJ; Parker Institute for Cancer Immunotherapy, University of Pennsylvania, Philadelphia, PA, USA.
Shi J; Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA, USA.
Minn AJ; Department of Cancer Biology, University of Pennsylvania, Philadelphia, PA, USA.

Nat Cancer ; 4(1): 43-61, 2023 01.

Article em En | MEDLINE | ID: mdl-36646856

Assuntos

Interferon Tipo I; Neoplasias; Animais; Humanos; Camundongos; Memória Epigenética; Inibidores de Checkpoint Imunológico/farmacologia; Inibidores de Checkpoint Imunológico/uso terapêutico; Interferon Tipo I/metabolismo; Interferon Tipo I/farmacologia; Interferon gama/genética; Interferon gama/metabolismo; Interferon gama/farmacologia; Neoplasias/tratamento farmacológico; Neoplasias/genética; Transdução de Sinais; Linfócitos T/imunologia

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Interferon Tipo I / Neoplasias Idioma: En Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos

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