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Immunoexpression of stem cell markers SOX-2, NANOG AND OCT4 in ameloblastoma.
Martins Balbinot, Karolyny; Almeida Loureiro, Felippe José; Chemelo, Giordanna Pereira; Alves Mesquita, Ricardo; Cruz Ramos, Aline Maria Pereira; Ramos, Rommel Thiago Jucá; da Costa da Silva, Artur Luiz; de Menezes, Sílvio Augusto Fernandes; da Silva Kataoka, Maria Sueli; Alves Junior, Sergio de Melo; Viana Pinheiro, João de Jesus.
Afiliação
  • Martins Balbinot K; Laboratory of Pathological Anatomy and Immunohistochemistry, Federal University of Pará, Belém, Pará, Brazil.
  • Almeida Loureiro FJ; Cell Cultivation Laboratory, Federal University of Pará, Belém, Pará, Brazil.
  • Chemelo GP; Cell Cultivation Laboratory, Federal University of Pará, Belém, Pará, Brazil.
  • Alves Mesquita R; Department of Oral Surgery and Pathology, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
  • Cruz Ramos AMP; Health Science Institute, Federal University of Pará, Belém, Pará, Brazil.
  • Ramos RTJ; Biological Engineer Laboratory, Park of Science and Technology, Belém, Pará, Brazil.
  • da Costa da Silva AL; Biological Engineer Laboratory, Park of Science and Technology, Belém, Pará, Brazil.
  • de Menezes SAF; Department of Periodontics, Pará State University, Belém, Pará, Brazil.
  • da Silva Kataoka MS; Cell Cultivation Laboratory, Federal University of Pará, Belém, Pará, Brazil.
  • Alves Junior SM; Laboratory of Pathological Anatomy and Immunohistochemistry, Federal University of Pará, Belém, Pará, Brazil.
  • Viana Pinheiro JJ; Cell Cultivation Laboratory, Federal University of Pará, Belém, Pará, Brazil.
PeerJ ; 11: e14349, 2023.
Article em En | MEDLINE | ID: mdl-36655039
Background: Ameloblastoma (AME) is characterized by a locally invasive growth pattern. In an attempt to justify the aggressiveness of neoplasms, the investigation of the role of stem cells has gained prominence. The SOX-2, NANOG and OCT4 proteins are important stem cell biomarkers. Methodology: To verify the expression of these proteins in tissue samples of AME, dentigerous cyst (DC) and dental follicle (DF), immunohistochemistry was performed and indirect immunofluorescence were performed on the human AME (AME-hTERT) cell line. Results: Revealed expression of SOX-2, NANOG and OCT4 in the tissue samples and AME-hTERT lineage. Greater immunostaining of the studied proteins was observed in AME compared to DC and DF (p < 0.001). Conclusions: The presence of biomarkers indicates a probable role of stem cells in the genesis and progression of AME.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células-Tronco Neoplásicas / Ameloblastoma Idioma: En Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células-Tronco Neoplásicas / Ameloblastoma Idioma: En Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Brasil