Ex Vivo Product Distribution of Injectable Biostimulator Substances.
Aesthet Surg J
; 43(5): NP348-NP356, 2023 04 10.
Article
em En
| MEDLINE
| ID: mdl-36662772
ABSTRACT
BACKGROUND:
Increasing demand for minimally invasive aesthetic treatments, such as injection of biostimulator substances to induce the production of extracellular matrix, has been reported. Recent studies have reported on a variety of different product characteristics influencing the integration and distribution of biostimulator substances after injection.OBJECTIVES:
The aim of this study was to analyze the ex vivo product integration and distribution behavior of 6 different biostimulator substances after injection.METHODS:
A total of n = 21 abdominal soft tissue flaps were analysed by real-time ultrasound imaging with regards to horizontal and vertical spread of 6 different injected biostimulator substances-based on hydroxylapatite (HA), polycaprolactone (PCL), and poly-L-lactic acid (PLLA)-immediately after injection and after massaging. The 6 different biostimulator substances were R-CaHA-based, H-CaHA-based, PCL-based, PLLA-1-based, PLLA-2-based and H-HA-based products.RESULTS:
Overall, the R-CaHA-, H-CaHA-, and PCL-based substances showed greater product spread after massaging when compared with the product distribution immediately after the injection with all P < .001 with the exception of the vertical dimension of the H-CaHA-based substance (P = .064). The PLLA-1-, PLLA-2-, and H-HA-based substances showed smaller product spread after massaging compared with the product distribution immediately after the injection with all P < .001 with the exception of the horizontal dimension of the H-HA-based substance (P = .314), indicating higher tissue integration.CONCLUSIONS:
Different biostimulator substances behave differently when injected into subcutaneous soft tissues; differences exist at the level of initial product diffusion and during tissue integration.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Envelhecimento da Pele
/
Técnicas Cosméticas
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article