Phosphoproteomics Profiling Defines a Target Landscape of the Basophilic Protein Kinases AKT, S6K, and RSK in Skeletal Myotubes.

Fricke, Anna L; Mühlhäuser, Wignand W D; Reimann, Lena; Zimmermann, Johannes P; Reichenbach, Christa; Knapp, Bettina; Peikert, Christian D; Heberle, Alexander M; Faessler, Erik; Schäuble, Sascha; Hahn, Udo; Thedieck, Kathrin; Radziwill, Gerald; Warscheid, Bettina

Fricke, Anna L; Mühlhäuser, Wignand W D; Reimann, Lena; Zimmermann, Johannes P; Reichenbach, Christa; Knapp, Bettina; Peikert, Christian D; Heberle, Alexander M; Faessler, Erik; Schäuble, Sascha; Hahn, Udo; Thedieck, Kathrin; Radziwill, Gerald; Warscheid, Bettina.

Afiliação

Fricke AL; Biochemistry and Functional Proteomics, Institute of Biology II, Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany.
Mühlhäuser WWD; Biochemistry II, Theodor Boveri-Institute, Biocenter, University of Würzburg, 97074 Würzburg, Germany.
Reimann L; Biochemistry and Functional Proteomics, Institute of Biology II, Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany.
Zimmermann JP; Biochemistry and Functional Proteomics, Institute of Biology II, Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany.
Reichenbach C; Biochemistry II, Theodor Boveri-Institute, Biocenter, University of Würzburg, 97074 Würzburg, Germany.
Knapp B; Biochemistry and Functional Proteomics, Institute of Biology II, Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany.
Peikert CD; Biochemistry and Functional Proteomics, Institute of Biology II, Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany.
Heberle AM; Biochemistry and Functional Proteomics, Institute of Biology II, Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany.
Faessler E; Institute of Biochemistry and Center for Molecular Biosciences Innsbruck, University of Innsbruck, 6020 Innsbruck, Austria.
Schäuble S; Jena University Language & Information Engineering (JULIE) Lab, Friedrich Schiller University Jena, 07743 Jena, Germany.
Hahn U; Jena University Language & Information Engineering (JULIE) Lab, Friedrich Schiller University Jena, 07743 Jena, Germany.
Thedieck K; Systems Biology and Bioinformatics Unit, Leibniz Institute for Natural Product Research and Infection BiologyâLeibniz-HKI, 07745 Jena, Germany.
Radziwill G; Jena University Language & Information Engineering (JULIE) Lab, Friedrich Schiller University Jena, 07743 Jena, Germany.
Warscheid B; Institute of Biochemistry and Center for Molecular Biosciences Innsbruck, University of Innsbruck, 6020 Innsbruck, Austria.

J Proteome Res ; 22(3): 768-789, 2023 03 03.

Article em En | MEDLINE | ID: mdl-36763541

Assuntos

Fosfatidilinositol 3-Quinases; Proteínas Proto-Oncogênicas c-akt; Fibras Musculares Esqueléticas/metabolismo; Fosfatidilinositol 3-Quinases/metabolismo; Fosforilação; Proteínas Proto-Oncogênicas c-akt/genética; Proteínas Proto-Oncogênicas c-akt/metabolismo; Transdução de Sinais/fisiologia; Proteínas Quinases S6 Ribossômicas 90-kDa; Proteínas Quinases S6 Ribossômicas 70-kDa

Palavras-chave

RXRXXS/T motif; cross talk; kinase inhibitors; kinase−substrate enrichment analysis (KSEA); kinase−substrate relationship; label-free; mass spectrometry; parallel reaction monitoring (PRM); protein phosphorylation; quantification; signal transduction; skeletal muscle cells; stable isotope labeling by amino acids in cell culture; text mining

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fosfatidilinositol 3-Quinases / Proteínas Proto-Oncogênicas c-akt Idioma: En Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Alemanha

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