Functions of Steroid Hormones in the Male Reproductive Tract as Revealed by Mouse Models.
Int J Mol Sci
; 24(3)2023 Feb 01.
Article
em En
| MEDLINE
| ID: mdl-36769069
ABSTRACT
Steroid hormones are capable of diffusing through cell membranes to bind with intracellular receptors to regulate numerous physiological processes. Three classes of steroid hormones, namely androgens, estrogens and glucocorticoids, contribute to the development of the reproductive system and the maintenance of fertility. During the past 30 years, mouse models have been produced in which the expression of genes encoding steroid hormone receptors has been enhanced, partially compromised or eliminated. These mouse models have revealed many of the physiological processes regulated by androgens, estrogens and to a more limited extent glucocorticoids in the testis and male accessory organs. In this review, advances provided by mouse models that have facilitated a better understanding of the molecular regulation of testis and reproductive tract processes by steroid hormones are discussed.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Glucocorticoides
/
Androgênios
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Estados Unidos