Influence of antiresorptive/antiangiogenic therapy on the extension of experimentally induced peri-implantitis lesions.
Clin Oral Investig
; 27(6): 3009-3019, 2023 Jun.
Article
em En
| MEDLINE
| ID: mdl-36800025
ABSTRACT
OBJECTIVES:
To investigate the extension of experimentally induced peri-implantitis lesions under various antiresorptive and antiangiogenic medications. MATERIAL ANDMETHODS:
Fourty-eight albino rats had randomly received the following medications (dual application, n = 8 each) (1) amino-bisphosphonate (zoledronate) (Zo), (2) RANKL inhibitor (denosumab) (De), (3) antiangiogenic (bevacizumab) (Be), (4) Zo+Be, (5) De+Be, or (6) no medication (Co). Ligature- and lipopolysaccharide-induced peri-implantitis lesions were established at 2 maxillary implants over a period of 16 weeks. Histological (e.g., apical extension and surface area of the inflammatory cell infiltrate-aICT, ICT; defect length; defect width; CD68 positive cells) and bone micromorphometric (µCT) outcomes were assessed. The animal was defined as a statistical unit.RESULTS:
A total of n = 38 animals (Zo = 6, De = 6, Be = 8, Zo + Be = 6, De + Be = 5, Co = 7) were analyzed. ICT's were commonly marked by a positive CD68 antigen reactivity. Comparable median aICT (lowest-Zo 0.53 mm; highest-Be 1.22 mm), ICT (lowest-De + Be 0.00 mm2; highest-Co 0.49 mm2), defect length (lowest-Zo 0.90 mm; highest-Co 1.93 mm) and defect width (lowest-De+Be 1.27 mm; highest-Be 1.80 mm) values were noted in all test and control groups. Within an inner (diameter 0.8 mm) cylindric volume of interest, the bone microstructure did not significantly differ between groups.CONCLUSIONS:
The present analysis did not reveal any marked effects of various antiresorptive/ antiangiogenic medications on the extension of experimentally induced peri-implantitis lesions. CLINICAL RELEVANCE The extension of peri-implantitis lesions may not be facilitated by the antiresorptive and antiangiogenic medications investigated.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Implantes Dentários
/
Estimulação Elétrica Nervosa Transcutânea
/
Peri-Implantite
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article
País de afiliação:
Alemanha