Production of rAAV by plasmid transfection induces antiviral and inflammatory responses in suspension HEK293 cells.

Chung, Cheng-Han; Murphy, Christopher M; Wingate, Vincent P; Pavlicek, Jeffrey W; Nakashima, Reiko; Wei, Wei; McCarty, Douglas; Rabinowitz, Joseph; Barton, Erik

Chung, Cheng-Han; Murphy, Christopher M; Wingate, Vincent P; Pavlicek, Jeffrey W; Nakashima, Reiko; Wei, Wei; McCarty, Douglas; Rabinowitz, Joseph; Barton, Erik.

Afiliação

Chung CH; Pfizer Inc., Worldwide Research, Development and Medical, Bioprocess Research and Development, Morrisville, NC 27560, USA.
Murphy CM; Pfizer Inc., Worldwide Research, Development and Medical, Bioprocess Research and Development, Morrisville, NC 27560, USA.
Wingate VP; Pfizer Inc., Worldwide Research, Development and Medical, Bioprocess Research and Development, Morrisville, NC 27560, USA.
Pavlicek JW; Pfizer Inc., Worldwide Research, Development and Medical, Bioprocess Research and Development, Morrisville, NC 27560, USA.
Nakashima R; Pfizer Inc., Worldwide Research, Development and Medical, Simulation and Modeling Sciences, Cambridge, MA 02139, USA.
Wei W; Pfizer Inc., Worldwide Research, Development and Medical, Bioprocess Research and Development, Morrisville, NC 27560, USA.
McCarty D; Pfizer Inc., Worldwide Research, Development and Medical, Rare Disease Research Unit, Morrisville, NC 27560, USA.
Rabinowitz J; Pfizer Inc., Worldwide Research, Development and Medical, Rare Disease Research Unit, Morrisville, NC 27560, USA.
Barton E; Pfizer Inc., Worldwide Research, Development and Medical, Bioprocess Research and Development, Morrisville, NC 27560, USA.

Mol Ther Methods Clin Dev ; 28: 272-283, 2023 Mar 09.

Article em En | MEDLINE | ID: mdl-36819978

Palavras-chave

AAV; Gene Ontology; antiviral response; gene therapy; host cell response; inflammatory response; innate immune response; time-series analysis; transcriptome analysis; viral vector manufacturing

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo

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XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos