Immunoinformatics-aided design of a new multi-epitope vaccine adjuvanted with domain 4 of pneumolysin against Streptococcus pneumoniae strains.

Shafaghi, Mona; Bahadori, Zohreh; Madanchi, Hamid; Ranjbar, Mohammad Mehdi; Shabani, Ali Akbar; Mousavi, Seyed Fazlollah

Shafaghi, Mona; Bahadori, Zohreh; Madanchi, Hamid; Ranjbar, Mohammad Mehdi; Shabani, Ali Akbar; Mousavi, Seyed Fazlollah.

Afiliação

Shafaghi M; Department of Medical Biotechnology, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran.
Bahadori Z; Research Center of Biotechnology, Semnan University of Medical Sciences, Semnan, Iran.
Madanchi H; Department of Bacteriology, Pasteur Institute of Iran, Tehran, Iran.
Ranjbar MM; Department of Medical Biotechnology, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran.
Shabani AA; Research Center of Biotechnology, Semnan University of Medical Sciences, Semnan, Iran.
Mousavi SF; Department of Bacteriology, Pasteur Institute of Iran, Tehran, Iran.

BMC Bioinformatics ; 24(1): 67, 2023 Feb 24.

Article em En | MEDLINE | ID: mdl-36829109

Assuntos

COVID-19; Streptococcus pneumoniae; Criança; Humanos; Pré-Escolar; Idoso; Simulação de Acoplamento Molecular; Escherichia coli; Receptor 4 Toll-Like; Epitopos de Linfócito T/química; Vacinas de Subunidades Antigênicas/química; Vacinas de Subunidades Antigênicas/genética; Epitopos de Linfócito B; Biologia Computacional/métodos

Palavras-chave

Domain 4 of pneumolysin (Ply4); Immunoinformatics; Multi-epitope vaccine; Pneumococcal histidine triad protein D (PhtD); Pneumococcal surface protein A (PspA); Protein TLR agonist adjuvant

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Streptococcus pneumoniae / COVID-19 Idioma: En Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Irã

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