Hypochlorous Acid and Chloramines Induce Specific Fragmentation and Cross-Linking of the G1-IGD-G2 Domains of Recombinant Human Aggrecan, and Inhibit ADAMTS1 Activity.

Wang, Yihe; Hammer, Astrid; Hoefler, Gerald; Malle, Ernst; Hawkins, Clare L; Chuang, Christine Y; Davies, Michael J

Wang, Yihe; Hammer, Astrid; Hoefler, Gerald; Malle, Ernst; Hawkins, Clare L; Chuang, Christine Y; Davies, Michael J.

Afiliação

Wang Y; Department of Biomedical Sciences, Panum Institute, University of Copenhagen, 2200 Copenhagen, Denmark.
Hammer A; Division of Cell Biology, Histology and Embryology, Gottfried Schatz Research Center, Medical University of Graz, 8010 Graz, Austria.
Hoefler G; Institute of Pathology, Diagnostic & Research Center for Molecular BioMedicine, Medical University of Graz, 8010 Graz, Austria.
Malle E; Division of Molecular Biology and Biochemistry, Gottfried Schatz Research Center, Medical University of Graz, 8010 Graz, Austria.
Hawkins CL; Department of Biomedical Sciences, Panum Institute, University of Copenhagen, 2200 Copenhagen, Denmark.
Chuang CY; Department of Biomedical Sciences, Panum Institute, University of Copenhagen, 2200 Copenhagen, Denmark.
Davies MJ; Department of Biomedical Sciences, Panum Institute, University of Copenhagen, 2200 Copenhagen, Denmark.

Antioxidants (Basel) ; 12(2)2023 Feb 08.

Article em En | MEDLINE | ID: mdl-36829979

Palavras-chave

ADAMTS; MPO-H2O2-Cl− system; aggrecan; chloramines; extracellular matrix; hypochlorous acid; myeloperoxidase; protein oxidation

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Dinamarca

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Dinamarca