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COVID-19 mRNA Vaccine Effectiveness against Elderly Frail People.
Kountouras, Jannis; Tzitiridou-Chatzopoulou, Maria; Papaefthymiou, Apostolis; Chatzopoulos, Dimitrios; Doulberis, Michael.
Afiliação
  • Kountouras J; Second Medical Clinic, School of Medicine, Ippokration Hospital, Aristotle University of Thessaloniki, 54642 Thessaloniki, Greece.
  • Tzitiridou-Chatzopoulou M; Second Medical Clinic, School of Medicine, Ippokration Hospital, Aristotle University of Thessaloniki, 54642 Thessaloniki, Greece.
  • Papaefthymiou A; Midwifery Department, School of Healthcare Sciences, University of West Macedonia, Koila, 50100 Kozani, Greece.
  • Chatzopoulos D; Second Medical Clinic, School of Medicine, Ippokration Hospital, Aristotle University of Thessaloniki, 54642 Thessaloniki, Greece.
  • Doulberis M; Department of Gastroenterology, University Hospital of Larisa, 41110 Larisa, Greece.
Medicina (Kaunas) ; 59(2)2023 Jan 19.
Article em En | MEDLINE | ID: mdl-36837403
The frail, elderly population is often characterized by poor immunogenicity post COVID-19 mRNA vaccination. "Inflame-ageing" and "immune-senescence" are pathogenetic mechanisms that might explain this phenomenon. Complex interplay with cytokines and microbiota is also implicated in this inflammatory cascade. The abovementioned population, although very important from immunologic perspective, has barely been included in the mRNA vaccination clinical trials.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Idoso Fragilizado / COVID-19 Idioma: En Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Grécia
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Idoso Fragilizado / COVID-19 Idioma: En Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Grécia