Direct inhibition of bisphenols on human and rat 11ß-hydroxysteroid dehydrogenase 2: Structure-activity relationship and docking analysis.

Zhang, Bingru; Wang, Shaowei; Tang, Yunbing; Hu, Zhiyan; Shi, Lei; Lu, Jialin; Li, Huitao; Wang, Yiyan; Zhu, Yang; Lin, Han; Ge, Ren-Shan

Zhang, Bingru; Wang, Shaowei; Tang, Yunbing; Hu, Zhiyan; Shi, Lei; Lu, Jialin; Li, Huitao; Wang, Yiyan; Zhu, Yang; Lin, Han; Ge, Ren-Shan.

Afiliação

Zhang B; Department of Anaesthesiology, the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, China; Key Laboratory of Environment and Male Reproductive Medicine of Wenzhou and Key Laboratory of Structural Malformations in Children of Zhejiang
Wang S; Department of Obstetrics and Gynecology, the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, China.
Tang Y; Department of Obstetrics and Gynecology, the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, China.
Hu Z; Department of Anaesthesiology, the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, China.
Shi L; Department of Obstetrics and Gynecology, the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, China.
Lu J; Department of Anaesthesiology, the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, China.
Li H; Department of Anaesthesiology, the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, China.
Wang Y; Department of Anaesthesiology, the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, China.
Zhu Y; Department of Anaesthesiology, the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, China.
Lin H; Department of Anaesthesiology, the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, China.
Ge RS; Department of Anaesthesiology, the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, China; Department of Obstetrics and Gynecology, the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou,

Ecotoxicol Environ Saf ; 254: 114715, 2023 Apr 01.

Article em En | MEDLINE | ID: mdl-36871355

Assuntos

Glucocorticoides; Placenta; Ratos; Humanos; Gravidez; Feminino; Animais; Glucocorticoides/metabolismo; 11-beta-Hidroxiesteroide Desidrogenases/metabolismo; Placenta/metabolismo; 11-beta-Hidroxiesteroide Desidrogenase Tipo 2/química; 11-beta-Hidroxiesteroide Desidrogenase Tipo 2/metabolismo; Relação Estrutura-Atividade

Palavras-chave

11-dehydrocorticosterone; Bisphenol analogues; Cortisol; Glucocorticoid; Kidney; Placenta

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Placenta / Glucocorticoides Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo

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PubMed Links

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Placenta / Glucocorticoides Idioma: En Ano de publicação: 2023 Tipo de documento: Article