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CYP3A4 Catalyzes the Rearrangement of the Dual Orexin Receptor Antagonist Daridorexant to 4-Hydroxypiperidinol Metabolites.
Treiber, Alexander; Aissaoui, Hamed; Delahaye, Stéphane; Glutz, Sven; Grimont, Julien; Müller, Claus; Seeland, Swen; Siefken, Valérie; Boss, Christoph.
Afiliação
  • Treiber A; Non-Clinical Drug Metabolism and Pharmacokinetics, Idorsia Pharmaceuticals Ltd., Hegenheimermattweg 91, 4123, Allschwil, Switzerland.
  • Aissaoui H; Drug Discovery Chemistry, Idorsia Pharmaceuticals Ltd., Hegenheimermattweg 91, 4123, Allschwil, Switzerland.
  • Delahaye S; Non-Clinical Drug Metabolism and Pharmacokinetics, Idorsia Pharmaceuticals Ltd., Hegenheimermattweg 91, 4123, Allschwil, Switzerland.
  • Glutz S; Drug Discovery Chemistry, Idorsia Pharmaceuticals Ltd., Hegenheimermattweg 91, 4123, Allschwil, Switzerland.
  • Grimont J; Drug Discovery Chemistry, Idorsia Pharmaceuticals Ltd., Hegenheimermattweg 91, 4123, Allschwil, Switzerland.
  • Müller C; Drug Discovery Chemistry, Idorsia Pharmaceuticals Ltd., Hegenheimermattweg 91, 4123, Allschwil, Switzerland.
  • Seeland S; Non-Clinical Drug Metabolism and Pharmacokinetics, Idorsia Pharmaceuticals Ltd., Hegenheimermattweg 91, 4123, Allschwil, Switzerland.
  • Siefken V; Drug Discovery Chemistry, Idorsia Pharmaceuticals Ltd., Hegenheimermattweg 91, 4123, Allschwil, Switzerland.
  • Boss C; Drug Discovery Chemistry, Idorsia Pharmaceuticals Ltd., Hegenheimermattweg 91, 4123, Allschwil, Switzerland.
ChemMedChem ; 18(10): e202300030, 2023 05 16.
Article em En | MEDLINE | ID: mdl-36892179
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Citocromo P-450 CYP3A / Antagonistas dos Receptores de Orexina Idioma: En Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Suíça
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Citocromo P-450 CYP3A / Antagonistas dos Receptores de Orexina Idioma: En Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Suíça